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Regulation of phospholipase C-delta by GTP-binding proteins-rhoA as an inhibitory modulator
- Source :
- Biochimica et biophysica acta. 1403(1)
- Publication Year :
- 1998
-
Abstract
- The regulation of Phospholipase C (PLC)delta activity remains obscure. These studies show that PLCdelta1 activity is significantly enhanced by both guanosine thiotriphosphate (GTPgammaS) and Clostridium botulinum exoenzyme C3 (C3) but not by aluminium fluoride. C3 ADP ribosylated a 21-kDa protein in the PLCdelta1 preparation and Western blotting identified rhoA in these samples. RhoA acts as an inhibitory modulator of PLCdelta activity.
- Subjects :
- RHOA
Botulinum Toxins
G protein
Antidotes
GTPgammaS
Guanosine
GTP-binding protein
Chemical Fractionation
Deferoxamine
Sulfur Radioisotopes
GTP Phosphohydrolases
chemistry.chemical_compound
Phospholipase C delta
GTP-binding protein regulators
Adenosine Triphosphate
GTP-Binding Proteins
Animals
Molecular Biology
Exoenzyme C3
ADP Ribose Transferases
Adenosine Diphosphate Ribose
Phospholipase C
biology
Guanosine 5'-O-(3-Thiotriphosphate)
RhoA
Cell Biology
Molecular biology
Phospholipase Cδ1
Enzyme Activation
Isoenzymes
chemistry
Biochemistry
Type C Phospholipases
biology.protein
Sodium Fluoride
Cattle
rhoA GTP-Binding Protein
Subjects
Details
- ISSN :
- 00063002
- Volume :
- 1403
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Biochimica et biophysica acta
- Accession number :
- edsair.doi.dedup.....611fc4bb600ded8eae10981aa251c97c