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An improved axillary staging system using the OSNA assay does not modify the therapeutic management of breast cancer patients
- Source :
- Scientific Reports
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- The one-step nucleic acid amplification (OSNA) assay is a molecular procedure that can identify deposits of breast cancer (BC) cells in the sentinel lymph node (SLN). We examined the consistency of the OSNA assay with a classic hematoxylin-eosin (H&E)-based immunohistochemistry (IHC) study and evaluated how OSNA-based axillary staging might impact the therapeutic management of BC patients. SLN biopsy results were considered to be positive in 60 patients (40%) in the OSNA group (N = 148) and in 43 (28%) patients in the IHC cohort (N = 153, p = 0.023). There was no difference in the macrometastasis (22% for OSNA, 15% for H&E, p = 0.139) or micrometastasis (19% for OSNA, 13% for H&E, p = 0.166) rates, but we found statistically significant differences in the number of isolated tumor cells (1% for OSNA, 11% for H&E, p < 0.001). There were no differences in the administration rate of adjuvant systemic therapy between the OSNA (66% in the SLN+ patients) and the H&E (74% in the SLN+ patients) groups (p = 0.159). The OSNA assay allows for the detection of SLN metastases more precisely than conventional pathologic methods but does not alter the therapeutic management of SLN+ BC patients.
- Subjects :
- Adult
medicine.medical_specialty
Pathology
Sentinel lymph node
Breast Neoplasms
Gastroenterology
Article
Breast cancer
Internal medicine
Biopsy
medicine
Carcinoma
Humans
Macrometastasis
Aged
Neoplasm Staging
Multidisciplinary
medicine.diagnostic_test
business.industry
Carcinoma, Ductal, Breast
Micrometastasis
Nucleic acid amplification technique
Middle Aged
medicine.disease
Quality Improvement
Axilla
medicine.anatomical_structure
Molecular Diagnostic Techniques
Chemotherapy, Adjuvant
Lymphatic Metastasis
Female
Lymph Nodes
business
Nucleic Acid Amplification Techniques
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....6166e22c07abd59adb991e413c19f124