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Recurrent erythema multiforme triggered by progesterone sensitivity
- Source :
- Journal of cutaneous pathology. 37(11)
- Publication Year :
- 2010
-
Abstract
- Determining the underlying etiology of recurrent erythema multiforme (EM) can be a difficult endeavor. Although infection with herpes simplex virus (HSV) has been implicated in some cases, the precise trigger of a given patient's recurrent EM often remains elusive. We discuss the case of a woman with a recurrent blistering eruption that was clinically and histopathologically consistent with EM. An investigation into the etiology of the patient's EM suggested that HSV was not the causative factor but instead pointed toward a hormonal influence that we interpret as autoimmune progesterone dermatitis (APD). This case is presented to highlight the importance of considering hormonal triggers in women with recurrent EM that consistently flares during the luteal phase of the menstrual cycle, the point at which serum progesterone levels peak. A brief review of the literature regarding the diagnosis, histopathology, etiology and treatment of APD is further provided.
- Subjects :
- Pathology
medicine.medical_specialty
Histology
media_common.quotation_subject
Dermatitis
Dermatology
Luteal phase
Pathology and Forensic Medicine
Autoimmune Diseases
Young Adult
medicine
Humans
Erythema multiforme
Young adult
Menstrual cycle
Progesterone
media_common
Erythema Multiforme
business.industry
Anatomical pathology
medicine.disease
Immunology
Etiology
Histopathology
Female
Autoimmune progesterone dermatitis
business
Subjects
Details
- ISSN :
- 16000560
- Volume :
- 37
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of cutaneous pathology
- Accession number :
- edsair.doi.dedup.....6169139b46ab57e9d3c2089c1fdbc024