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Inflammation and Immunity in Radiation Damage to the Gut Mucosa
- Source :
- BioMed Research International, BioMed Research International, 2013, 2013, ⟨10.1155/2013/123241⟩, BioMed Research International, Vol 2013 (2013)
- Publication Year :
- 2013
- Publisher :
- Hindawi Publishing Corporation, 2013.
-
Abstract
- Erythema was observed on the skin of the first patients treated with radiation therapy. It is in particular to reduce this erythema, one feature of tissue inflammation, that prescribed dose to the tumor site started to be fractionated. It is now well known that radiation exposure of normal tissues generates a sustained and apparently uncontrolled inflammatory process. Radiation-induced inflammation is always observed, often described, sometimes partly explained, but still today far from being completely understood. The thing with the gut and especially the gut mucosa is that it is at the frontier between the external milieu and the organism, is in contact with a plethora of commensal and foreign antigens, possesses a dense-associated lymphoid tissue, and is particularly radiation sensitive because of a high mucosal turnover rate. All these characteristics make the gut mucosa a strong responsive organ in terms of radiation-induced immunoinflammation. This paper will focus on what has been observed in the normal gut and what remains to be done concerning the immunoinflammatory response following localized radiation exposure. © 2013 Agnès François et al.
- Subjects :
- Pathology
Erythema
pattern recognition receptor
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
lcsh:Medicine
radiation exposure
Review Article
reactive oxygen metabolite
digestive system inflammation
immune response
soft tissue inflammation
immunology
0302 clinical medicine
Neoplasms
homeostasis
pelvis cancer
innate immunity
mucosa
cellular distribution
0303 health sciences
Gastrointestinal tract
Radiation
pathogenesis
Mucous membrane
toll like receptor
neutrophil
General Medicine
adaptive immunity
prostate cancer
3. Good health
radiation dose fractionation
cell polarity
medicine.anatomical_structure
Lymphatic system
cell death
cytokine release
030220 oncology & carcinogenesis
lymphoid cell
intestine mucosa
gastrointestinal mucosa
disease severity
medicine.symptom
Abnormalities
radiation dose
vascular endothelium
radiation injury
medicine.medical_specialty
congenital malformation
review
tumor localization
Inflammation
G protein coupled receptor
macrophage
Biology
proctitis
Abnormalities, Radiation-Induced
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
antigen
Antigen
Immunity
medicine
intestine motility
Humans
human
gastrointestinal toxicity
chymase
030304 developmental biology
Paneth cell
prescription
nonhuman
Mucous Membrane
General Immunology and Microbiology
Radiotherapy
lcsh:R
Radiation therapy
Gastrointestinal Tract
Radiation-Induced
radiosensitivity
Immunology
pathology
mast cell
neoplasm
Subjects
Details
- Language :
- English
- ISSN :
- 23146141 and 23146133
- Volume :
- 2013
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....618b2f502f308aa982039886ab1c1f24