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When Tissue is an Issue the Liquid Biopsy is Nonissue: A Review

Authors :
Andrés F. Cardona
July Rodriguez
Zyanya Lucia Zatarain-Barrón
Gonzalo Recondo
Alessandro Russo
Camila Ordóñez-Reyes
J. Ávila
Christian Rolfo
Alejandro Ruiz-Patiño
Luisa Ricaurte
Oscar Arrieta
Source :
Oncology and Therapy
Publication Year :
2021
Publisher :
Springer Science and Business Media LLC, 2021.

Abstract

Precision medicine has impacted the field of medical oncology by introducing personalized therapies, improving all measurable outcomes. This field, in turn, has expanded to obtaining and analyzing a vast and ever-increasing amount of genomic information. One technique currently applied is the liquid biopsy, which consists of detecting and isolating DNA and exosomes in cancer patients. Newly developed techniques have made it possible to use the liquid biopsy in a wide range of settings. However, challenges regarding the validation of its clinical utility exist because of a lack of standardization across different techniques and tumor types, confounder genomic information, lack of appropriate clinical trial designs, and a non-measured, and therefore not estimated, economic impact on population health. Nowadays, liquid biopsy is not routinely used, but ongoing research is increasing its popularity, and a new era in oncology is developing. Therefore, it is essential to have an in-depth understanding of the liquid biopsy technique. In this review, we summarize the leading techniques and liquid biopsy applications in cancer.

Details

ISSN :
23661089 and 23661070
Volume :
9
Database :
OpenAIRE
Journal :
Oncology and Therapy
Accession number :
edsair.doi.dedup.....61baefa4ee3eef83ad73ecafe81e1541
Full Text :
https://doi.org/10.1007/s40487-021-00144-6