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Spirocyclic NK(1) antagonists II: [4.5]-spiroethers
- Source :
- Bioorganicmedicinal chemistry letters. 12(19)
- Publication Year :
- 2002
-
Abstract
- A series of novel spiroether-based neurokinin-1 (NK 1 ) antagonists is described. The effect of modifications to the spiroether ring and aromatic substituents are discussed, leading to the identification of compounds with high affinity and excellent CNS penetration.
- Subjects :
- Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
CHO Cells
Biochemistry
Chemical synthesis
Binding, Competitive
Cns penetration
Dogs
Spiroether
Neurokinin-1 Receptor Antagonists
Cricetinae
Drug Discovery
Animals
Humans
Spiro Compounds
Molecular Biology
Bicyclic molecule
Behavior, Animal
Chemistry
Organic Chemistry
Ferrets
Biological activity
Rats
Molecular Medicine
Antiemetics
Gerbillinae
Ethers
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 12
- Issue :
- 19
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....61c481783ca41840cddd86d1c26a2fe5