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Mitochondrial abnormalities in human immunodeficiency virus-associated myopathy
Mitochondrial abnormalities in human immunodeficiency virus-associated myopathy
- Source :
- Acta Neuropathologica. 90:411-414
- Publication Year :
- 1995
- Publisher :
- Springer Science and Business Media LLC, 1995.
-
Abstract
- There is controversy as to whether zidovudine (ZDV) induces a mitochondrial myopathy that is distinguishable from human immunodeficiency virus (HIV)-associated myopathy in ZDV-naive patients. Mitochondrial abnormalities were evaluated in skeletal muscle obtained from 18 HIV-positive, ZDV-exposed patients, and 9 who were drug naive. All patients had clinical myopathy, and underwent neuromuscular evaluation with information recorded on timing and dosage of ZDV. All underwent muscle biopsies and samples were examined without knowledge of clinical history or ZDV status. Biopsy samples were evaluated by light and electron microscopy. Mitochondrial abnormalities were seen in ZDV-treated and -naive groups, and did not correlate with ZDV exposure or cumulative ZDV dosage. Mitochondrial abnormalities displayed significant correlation with the presence and severity of myofiber degeneration on biopsy, regardless of ZDV status. As mitochondrial abnormalities reflect myofiber degeneration, present in both patient groups, they may not be used as evidence of primary mitochondrial dysfunction. The etiology of myofiber degeneration in patients with HIV infection, whether ZDV-exposed or -naive, remains unclear.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Muscle Fibers, Skeletal
Pain
HIV Infections
Biology
Mitochondrion
Antiviral Agents
Pathology and Forensic Medicine
Pathogenesis
Zidovudine
Cellular and Molecular Neuroscience
Mitochondrial myopathy
Muscular Diseases
immune system diseases
Immunopathology
Biopsy
medicine
Humans
Myopathy
Creatine Kinase
Muscle Weakness
medicine.diagnostic_test
Muscles
virus diseases
Middle Aged
medicine.disease
Mitochondria, Muscle
Drug-naïve
Microscopy, Electron
Female
Neurology (clinical)
medicine.symptom
medicine.drug
Subjects
Details
- ISSN :
- 14320533 and 00016322
- Volume :
- 90
- Database :
- OpenAIRE
- Journal :
- Acta Neuropathologica
- Accession number :
- edsair.doi.dedup.....61cafe4b8b2388f0fa0e040c50f1e8fc
- Full Text :
- https://doi.org/10.1007/s004010050348