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Mitochondrial abnormalities in human immunodeficiency virus-associated myopathy

Mitochondrial abnormalities in human immunodeficiency virus-associated myopathy

Authors :
Michele Tagliati
Emilie Godfrey
Rikki Feinstein
David Wolfe
Susan Morgello
David M. Simpson
Source :
Acta Neuropathologica. 90:411-414
Publication Year :
1995
Publisher :
Springer Science and Business Media LLC, 1995.

Abstract

There is controversy as to whether zidovudine (ZDV) induces a mitochondrial myopathy that is distinguishable from human immunodeficiency virus (HIV)-associated myopathy in ZDV-naive patients. Mitochondrial abnormalities were evaluated in skeletal muscle obtained from 18 HIV-positive, ZDV-exposed patients, and 9 who were drug naive. All patients had clinical myopathy, and underwent neuromuscular evaluation with information recorded on timing and dosage of ZDV. All underwent muscle biopsies and samples were examined without knowledge of clinical history or ZDV status. Biopsy samples were evaluated by light and electron microscopy. Mitochondrial abnormalities were seen in ZDV-treated and -naive groups, and did not correlate with ZDV exposure or cumulative ZDV dosage. Mitochondrial abnormalities displayed significant correlation with the presence and severity of myofiber degeneration on biopsy, regardless of ZDV status. As mitochondrial abnormalities reflect myofiber degeneration, present in both patient groups, they may not be used as evidence of primary mitochondrial dysfunction. The etiology of myofiber degeneration in patients with HIV infection, whether ZDV-exposed or -naive, remains unclear.

Details

ISSN :
14320533 and 00016322
Volume :
90
Database :
OpenAIRE
Journal :
Acta Neuropathologica
Accession number :
edsair.doi.dedup.....61cafe4b8b2388f0fa0e040c50f1e8fc
Full Text :
https://doi.org/10.1007/s004010050348