Genetic associations of prolactin increase in olanzapine/fluoxetine combination-treated patients

Authors :: David H. Adams
John P. Houston
Bonnie Fijal
Alexandra N. Heinloth
Source :: Psychiatry Research. 175:171-172
Publication Year :: 2010
Publisher :: Elsevier BV, 2010.
Abstract: In patients from two clinical trials, we investigated the associations of single nucleotide polymorphisms (SNPs) in candidate genes with prolactin level changes during treatment with olanzapine/fluoxetine combination. In both cohorts, three dopamine receptor D2 (DRD2) SNPs were associated with prolactin changes. DRD2 may influence susceptibility to hyperprolactinemia associated with antipsychotic treatment.

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