Back to Search
Start Over
Enhanced UV♀1 tumor growth in CBF1 mice infected with Schistosoma mansoni due to modulation of Th1-like responses
- Source :
- Parasitology International. 51:177-186
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- Effects of Schistosoma mansoni infection on anti-tumor immunity were examined in CBF1 mice with ultraviolet-induced UVfemale1 fibrosarcoma cells. Although many laboratory established tumor cells had rejection mechanisms independent of CD4(+) T cells, we confirmed that CD4(+) cells had significant roles in rejection of UVfemale1 cells in the syngeneic CBF1 mice. When we prepared two CBF1 mouse groups, S. mansoni-infected and schistosome-free, the former group showed up-regulation of Th2-like response to UVfemale1 cells, whereas the latter group mice showed rather type 1-dominant patterns. Cytotoxic activity against UVfemale1 cells tested in vitro, which was attributed to CD8(+) cells, was significantly weaker in S. mansoni-infected mice compared with infection-free mice. In tumor challenge experiments in vivo, we observed that rapid and complete rejection of UVfemale1 cells required the presence of CD8(+) T cells. Under only CD4-depleted situation, survival of tumor cells in schistosome-free mice was prolonged up to 1 month or more. Under the presence of both CD4(+) and CD8(+) cells, S. mansoni infected mice rejected the challenged UVfemale1 cells as was seen in normal mice. However, when CD8(+) cells were depleted from S. mansoni-infected mice, inoculated UVfemale1 cells grew more rapidly than in infection-free mice. Our results suggest that functionally polarized cytokine patterns in schistosome-infected hosts promote rapid tumor growth.
- Subjects :
- CD4-Positive T-Lymphocytes
Graft Rejection
Ultraviolet Rays
Fibrosarcoma
Neoplasms, Fibrous Tissue
medicine.medical_treatment
Mice, Nude
CD8-Positive T-Lymphocytes
Mice
Immunity
In vivo
Tumor Cells, Cultured
medicine
Animals
Cytotoxic T cell
Mice, Inbred BALB C
biology
Schistosoma mansoni
Th1 Cells
biology.organism_classification
medicine.disease
Molecular biology
Schistosomiasis mansoni
In vitro
Mice, Inbred C57BL
Transplantation, Isogeneic
Infectious Diseases
Cytokine
Immunology
Cytokines
Female
Immunization
Parasitology
CD8
Subjects
Details
- ISSN :
- 13835769
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Parasitology International
- Accession number :
- edsair.doi.dedup.....61d2d640e429bb9296f4942670eb3325
- Full Text :
- https://doi.org/10.1016/s1383-5769(02)00012-0