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A nickel-alkyl bond in an inactivated state of the enzyme catalyzing methane formation

Authors :
Bernhard Jaun
Jeffrey Harmer
Meike Goenrich
Rafal Piskorski
Rudolf K. Thauer
Dariush Hinderberger
Arthur Schweiger
Publication Year :
2016

Abstract

(Chemical Equation Presented) The spin reveals all: Electron paramagnetic resonance spectroscopy reveals the formation of a nickel-alkyl bond in the active site of methyl-coenzyme M reductase (MCR), the key enzyme of methanogenesis, when active MCRred1 reacts with the irreversible inhibitor 3-bromopropane sulfonate to form the MCRBPS species. © 2006 Wiley-VCH Verlag GmbH and Co. KGaA.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....61de32fd08332c90d11ed9f84c83351e