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Visual outcome of photodynamic therapy for typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy over 5 years of follow-up
- Source :
- Japanese Journal of Ophthalmology. 57:301-307
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- To evaluate the long-term effects of photodynamic therapy (PDT) on typical neovascular age-related macular degeneration (tAMD) and polypoidal choroidal vasculopathy (PCV). This was a multicenter prospective study of 139 eyes from 136 patients (tAMD: 74 eyes; PCV: 65 eyes) who underwent PDT as the initial treatment. The change in best-corrected visual acuity (BCVA), predictive factors for the BCVA at 60 months, frequency of recurrence, and mean recurrence period were analyzed. The pre-PDT BCVA and greatest linear dimension (GLD) did not differ between the two groups. The mean BCVA (logMAR) was significantly improved at 6 months post-initial PDT (post-PDT) in the PCV group (−0.11, P = 0.0091). However, at 60 months post-PDT, the mean BCVA was significantly worse than baseline in the tAMD (+0.21, P = 0.0035) and PCV (+0.21, P = 0.0076) groups. Pre-PDT BCVA, age, and GLD were the factors significantly associated with the BCVA at 60 months post-PDT. Although the frequency of recurrence did not significantly differ between the two phenotype groups, the mean recurrence period was significantly longer in the PCV group than in the tAMD group (15.7 vs. 8.6 months, P = 0.0020). PDT may not have benefits for visual acuity in cases of tAMD and PCV over 5 years of follow-up.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Visual acuity
genetic structures
Fundus Oculi
medicine.medical_treatment
Visual Acuity
Photodynamic therapy
Macular Degeneration
Ophthalmology
Age related
Humans
Medicine
Initial treatment
Prospective Studies
Fluorescein Angiography
Prospective cohort study
Aged
Photosensitizing Agents
Choroid
business.industry
Choroid Diseases
General Medicine
Macular degeneration
medicine.disease
eye diseases
Treatment Outcome
Photochemotherapy
Multicenter study
Female
sense organs
medicine.symptom
business
Follow-Up Studies
Linear dimension
Subjects
Details
- ISSN :
- 16132246 and 00215155
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Japanese Journal of Ophthalmology
- Accession number :
- edsair.doi.dedup.....61e5eb44192829865c06b5db35eb5dc3