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Evaluation of the paw withdrawal latency for the comparison between tramadol and butorphanol administered locally, in the plantar surface of rat, preliminary study
- Source :
- PLoS ONE, Vol 16, Iss 7, p e0254497 (2021), PLoS ONE
- Publication Year :
- 2021
- Publisher :
- Public Library of Science (PLoS), 2021.
-
Abstract
- The aim of the study was to evaluate the analgesic efficacy of tramadol compared to butorphanol administered locally in ventral surface of the hind paw of rats. Prospective, randomized experimental study; twenty-one adult male Wistar rats were selected. Heart rate (beats minute-1), respiratory rate (breaths minute-1), and paw withdrawal latency (onset of radiant heat until paw withdrawal/seconds) were measured prior (T0) and after (T5, T10, T15, T20) intraplantar injection with saline solution 0,9% (group S), butorphanol 1 mg kg-1 (group B), and tramadol 1 mg kg-1 (group T). Shapiro-Wilk normality test and Friedman test were used to analyze the data expressed by median and range. Statistical significance was set at p < 0.05. Statistical analysis of heart rate showed that there were significant differences between groups at different monitoring times. There were no significant differences in respiratory rate after intraplantar injection in any of the treatment groups. The paw withdrawal latency values at T5, T10, and T15 minutes after intraplantar injection in the group B were significantly higher compared to baseline value and to the values of the other groups. The paw withdrawal latency were no significant changes in the measurements of intragroup in S and T. Intraplantar administration of butorphanol provides a good analgesia and significantly increases paw withdrawal latency compared to tramadol. Intraplantar injection of butorphanol could be useful and safe and safe technique to achieve local analgesia for minor surgical procedures in rats.
- Subjects :
- medicine.medical_treatment
0403 veterinary science
0302 clinical medicine
Heart Rate
Anesthesiology
Medicine and Health Sciences
Anesthesia
Materials
Saline
Tramadol
Mammals
Analgesics
Multidisciplinary
Behavior, Animal
Pharmaceutics
Withdrawal latency
Drugs
Eukaryota
Animal Models
04 agricultural and veterinary sciences
Analgesics, Opioid
Solutions
Butorphanol
Experimental Organism Systems
Hyperalgesia
Vertebrates
Physical Sciences
Medicine
Research Article
medicine.drug
Drug Administration
Wistar Rats
Respiratory rate
040301 veterinary sciences
Science
Materials Science
Analgesic
Cardiology
Pain
Aqueous Solutions
Research and Analysis Methods
Rodents
03 medical and health sciences
Signs and Symptoms
Model Organisms
Respiratory Rate
Drug Therapy
Statistical significance
Heart rate
medicine
Animals
Humans
Pain Management
Rats, Wistar
Pharmacology
business.industry
Organisms
Biology and Life Sciences
030206 dentistry
Rats
Mixtures
Amniotes
Animal Studies
Local and Regional Anesthesia
Saline Solutions
Analgesia
Clinical Medicine
business
Zoology
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 16
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....61f9d90423673675053acbf1daf75ddb