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Dual trigger of oocyte maturation with gonadotropin-releasing hormone agonist and low-dose human chorionic gonadotropin to optimize live birth rates in high responders
- Source :
- Fertility and Sterility. 97:1316-1320
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- To compare live birth rates after dual trigger of oocyte maturation with GnRH agonist (GnRHa) and low-dose hCG versus GnRHa alone in high responders with peak E(2)4,000 pg/mL at risk of ovarian hyperstimulation syndrome (OHSS).Retrospective cohort study.University-based tertiary-care fertility center.Patients40 years old with peak E(2)4,000 pg/mL at risk of OHSS who underwent IVF/intracytoplasmic sperm injection with GnRH antagonist protocol and triggered with GnRHa alone or GnRHa plus 1,000 IU hCG (dual trigger) for oocyte maturation.GnRHa alone versus dual trigger.Live birth, implantation, and clinical pregnancy rates and OHSS.The dual-trigger group had a significantly higher live birth rate (52.9% vs. 30.9%), implantation rate (41.9% vs. 22.1%), and clinical pregnancy rate (58.8% vs. 36.8%) compared with the GnRHa trigger group. One case of mild OHSS occurred in the dual-trigger group, and there were no cases of OHSS in the GnRHa trigger group.Dual trigger of oocyte maturation with GnRHa and low-dose hCG in high responders with peak E(2)4,000 pg/mL improves the probability of conception and live birth without increasing the risk of significant OHSS.
- Subjects :
- Adult
Infertility
medicine.medical_specialty
Databases, Factual
Pregnancy Rate
medicine.drug_class
Ovarian hyperstimulation syndrome
Luteal Phase
Luteal phase
Chorionic Gonadotropin
Human chorionic gonadotropin
Gonadotropin-Releasing Hormone
Andrology
Ovarian Hyperstimulation Syndrome
Pregnancy
Risk Factors
Gonadotropin-releasing hormone agonist
Internal medicine
Humans
Medicine
Embryo Implantation
Retrospective Studies
Dose-Response Relationship, Drug
business.industry
Obstetrics and Gynecology
medicine.disease
Abortion, Spontaneous
Pregnancy rate
Endocrinology
Reproductive Medicine
Oocytes
Reproductive Control Agents
Drug Therapy, Combination
Female
business
Live birth
Infertility, Female
Subjects
Details
- ISSN :
- 00150282
- Volume :
- 97
- Database :
- OpenAIRE
- Journal :
- Fertility and Sterility
- Accession number :
- edsair.doi.dedup.....61ff2df5460dcad1d0c422804840c9cd
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2012.03.015