Back to Search
Start Over
A Dendritic Golgi Satellite between ERGIC and Retromer
- Source :
- Cell reports, 14(2): 189–199, Cell Reports, Vol 14, Iss 2, Pp 189-199 (2016)
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- SummaryThe local synthesis of transmembrane proteins underlies functional specialization of dendritic microdomains in neuronal plasticity. It is unclear whether these proteins have access to the complete machinery of the secretory pathway following local synthesis. In this study, we describe a probe called pGolt that allows visualization of Golgi-related organelles for live imaging in neurons. We show that pGolt labels a widespread microsecretory Golgi satellite (GS) system that is, in contrast to Golgi outposts, present throughout basal and apical dendrites of all pyramidal neurons. The GS system contains glycosylation machinery and is localized between ERGIC and retromer. Synaptic activity restrains lateral movement of ERGIC, GS, and retromer close to one another, allowing confined processing of secretory cargo. Several synaptic transmembrane proteins pass through and recycle back to the GS system. Thus, the presence of an ER-ERGIC-GS-retromer microsecretory system in all neuronal dendrites enables autonomous local control of transmembrane protein synthesis and processing.
- Subjects :
- 0301 basic medicine
Glycosylation
Retromer
Golgi Apparatus
Endoplasmic Reticulum
Bioinformatics
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
chemistry.chemical_compound
symbols.namesake
Live cell imaging
Organelle
lcsh:QH301-705.5
Secretory pathway
Neurons
Organelles
biology
Membrane Proteins
Dendrites
Golgi apparatus
biology.organism_classification
Transmembrane protein
Cell biology
030104 developmental biology
chemistry
lcsh:Biology (General)
nervous system
symbols
Satellite (biology)
Subjects
Details
- ISSN :
- 22111247
- Volume :
- 14
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cell Reports
- Accession number :
- edsair.doi.dedup.....620b7ad07fb2850e7775a0c9e807bb11
- Full Text :
- https://doi.org/10.1016/j.celrep.2015.12.024