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Effect of resveratrol on menstrual cyclicity, hyperandrogenism and metabolic profile in women with PCOS
- Source :
- Clinical Nutrition. 40:4106-4112
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Summary Aim The aim of this randomized trial was to find whether resveratrol could improve menstrual dysfunction, clinical signs (i.e., acne and hair loss), and the biochemical evidence of hyperandrogenism in the women with PCOS. Methods Women, in the age range of 18–40 years, diagnosed with PCOS, as defined by the Rotterdam criteria, and no other known cause of abnormal menstruation, were recruited. Participants were randomized based on a 1:1 ratio, to either 1000 mg resveratrol or 1000 mg placebo daily groups, for a period of 3 months. Results Seventy-eight patients were randomized: 39 to the resveratrol group and 39 to placebo. Results were analyzed according to the intention-to-treat principle. At the end of study, it was found that women who received resveratrol had a statistically higher regular menstruation rate, as compared to those who got placebo (76.47% vs. 51.61%; p = 0.03), and lower hair loss (32.10% vs. 68.00%; p = 0.009). We also found no significant differences between the two groups in terms of ovarian and adrenal androgens, sex hormone binding globulin (SHBG) levels, free androgen index (FAI), glycoinsulinemic metabolism and lipid profile. Moreover, the resveratrol treatment did not interfere with the thyroid, liver and kidney functions. The negative effect of resveratrol on the body composition was also observed, though not influencing changes in the weight, relative to the placebo group. Conclusion Resveratrol improved menstrual cyclicity and hair loss, even though levels of androgens, insulin and lipids remained unchanged.
- Subjects :
- Adult
0301 basic medicine
Adolescent
endocrine system diseases
Physiology
030209 endocrinology & metabolism
Resveratrol
Critical Care and Intensive Care Medicine
Placebo
Menstruation
Young Adult
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Sex hormone-binding globulin
Humans
Insulin
Medicine
Menstrual Cycle
030109 nutrition & dietetics
Nutrition and Dietetics
biology
medicine.diagnostic_test
business.industry
Free androgen index
Hyperandrogenism
Alopecia
medicine.disease
Lipids
Intention to Treat Analysis
Treatment Outcome
Hair loss
chemistry
Androgens
Body Composition
biology.protein
Female
business
Lipid profile
Polycystic Ovary Syndrome
Subjects
Details
- ISSN :
- 02615614
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Clinical Nutrition
- Accession number :
- edsair.doi.dedup.....621e8dc5f87ac9c86a1b7b91a06cd422