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Nipple Angiofibromas with Loss of TSC2 Are Associated with Tuberous Sclerosis Complex
- Source :
- The Journal of investigative dermatology
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Nevertheless, our ability to identify meaningful differences between these two populations suggests that this is a reasonable cutpoint. One hypothesis for the increasing incidence rates of early-onset BCC has been increased awareness and skin surveillance. However, lesion size has not decreased over time, as might be anticipated if earlier detection were the underlying cause of increased incidence (Christenson et al., 2005). Our results likewise suggest that early-onset BCC is associated with aggressive histologic characteristics, as opposed to a less aggressive phenotype that might be expected if surveillance bias were operating. Although additional studies are needed, these results suggest there may be underlying biological differences between earlyand late-onset BCC.
- Subjects :
- 0301 basic medicine
Surveillance Bias
medicine.medical_specialty
Dermatology
030105 genetics & heredity
Biochemistry
Article
Lesion
030207 dermatology & venereal diseases
03 medical and health sciences
Tuberous sclerosis
0302 clinical medicine
Medicine
Young adult
Molecular Biology
integumentary system
business.industry
Incidence (epidemiology)
Cell Biology
Angiofibroma
medicine.disease
Angiofibromas
medicine.symptom
TSC2
business
Subjects
Details
- ISSN :
- 0022202X
- Volume :
- 136
- Database :
- OpenAIRE
- Journal :
- Journal of Investigative Dermatology
- Accession number :
- edsair.doi.dedup.....62302e88d5eb5d7c7777799ab9f2fcfd