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Radiation-induced granulocyte transmigration predicts development of delayed structural changes in rat intestine
- Source :
- Radiotherapy and Oncology. 59:81-85
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- We examined whether early radiation-induced granulocyte transmigration (assessed by the fecal transferrin excretion ELISA assay) predicts subsequent development of (consequential) chronic radiation enteropathy. After accounting for the effect of radiation dose, transferrin excretion remained an independent predictor of overall tissue injury, intestinal fibrosis, and mucosal ulcers, but not TGF-β immunoreactivity.
- Subjects :
- medicine.medical_specialty
Pathology
Enzyme-Linked Immunosorbent Assay
Radiation induced
Granulocyte
Radiation Dosage
Radiation enteropathy
Excretion
Feces
Injury Severity Score
Cell Movement
Predictive Value of Tests
Reference Values
Transforming Growth Factor beta
Culture Techniques
Internal medicine
Intestine, Small
medicine
Mucosal Ulcer
Animals
Radiology, Nuclear Medicine and imaging
Probability
chemistry.chemical_classification
Rat intestine
business.industry
Transferrin
Dose-Response Relationship, Radiation
Hematology
medicine.disease
Rats
Disease Models, Animal
Radiation Injuries, Experimental
medicine.anatomical_structure
Endocrinology
ROC Curve
Oncology
chemistry
Multivariate Analysis
business
Granulocytes
Transforming growth factor
Subjects
Details
- ISSN :
- 01678140
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Radiotherapy and Oncology
- Accession number :
- edsair.doi.dedup.....62462c93a3535a61add9004365ed9098
- Full Text :
- https://doi.org/10.1016/s0167-8140(00)00302-9