Back to Search
Start Over
The role of serum lipoxin A4 levels in the association between periodontal disease and metabolic syndrome
The role of serum lipoxin A4 levels in the association between periodontal disease and metabolic syndrome
- Source :
- Journal of Periodontal & Implant Science
- Publication Year :
- 2019
-
Abstract
- Purpose An unresolved inflammatory state contributes to the pathogenesis of periodontal disease and metabolic syndrome (MetS). Therefore, the purpose of this study was to evaluate the role of lipoxin A4 (LXA4), a proresolving lipid mediator, in the association between periodontal disease and MetS. Methods Sixty-seven patients with MetS and 65 patients without MetS were included in the study. Sociodemographic information was obtained via a questionnaire, and detailed medical diagnoses were made. Periodontal parameters (plaque index [PI], gingival index [GI], probing pocket depth [PD], and clinical attachment level [CAL]) and metabolic parameters were measured, and serum LXA4 levels were determined. The associations among MetS, periodontal parameters, and serum LX levels were evaluated by adjusted multivariate linear regression analyses. Results Patients with MetS were older and had a higher body mass index than patients without MetS. Periodontal parameters (PI, GI, PD, and CAL) were higher in patients with MetS than in those without MetS. Serum LXA4 levels were higher in patients without MetS. Multivariate linear regression analysis indicated a positive association between MetS and periodontal parameters (PD and CAL). Negative associations were established between MetS and LXA4 levels, and between LXA4 and periodontal parameters (PI, PD, and CAL). Conclusions The presence of higher values of periodontal parameters in patients with MetS and the negative relationship of LXA4 with MetS and periodontal disease may support the protective role of proresolving lipid mediators in the association between periodontal disease and MetS.<br />Graphical Abstract
- Subjects :
- medicine.medical_specialty
Lipoxin a4
Plaque index
0206 medical engineering
02 engineering and technology
Gastroenterology
Periodontal Science
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Periodontal disease
Metabolic syndrome X
Internal medicine
Bayesian multivariate linear regression
medicine
In patient
Inflammation
business.industry
Periodontal diseases
030206 dentistry
medicine.disease
020601 biomedical engineering
Lipoxins
Periodontics
Oral Surgery
Metabolic syndrome
business
Body mass index
Research Article
Subjects
Details
- ISSN :
- 20932278
- Volume :
- 49
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of periodontalimplant science
- Accession number :
- edsair.doi.dedup.....628c8cc46c536ef8754020704f0ee0a1