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What Does the Future Hold for Yellow Fever Virus? (I)
- Source :
- Genes, Genes, 2018, 9 (6), pp.291. ⟨10.3390/genes9060291⟩, Genes, MDPI, 2018, 9 (6), pp.291. ⟨10.3390/genes9060291⟩, Genes, Vol 9, Iss 6, p 291 (2018)
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- As revealed by the recent resurgence of yellow fever virus (YFV) activity in the tropical regions of Africa and South America, YFV control measures need urgent rethinking. Over the last decade, most reported outbreaks occurred in, or eventually reached, areas with low vaccination coverage but that are suitable for virus transmission, with an unprecedented risk of expansion to densely populated territories in Africa, South America and Asia. As reflected in the World Health Organization’s initiative launched in 2017, it is high time to strengthen epidemiological surveillance to monitor accurately viral dissemination, and redefine vaccination recommendation areas. Vector-control and immunisation measures need to be adapted and vaccine manufacturing must be reconciled with an increasing demand. We will have to face more yellow fever (YF) cases in the upcoming years. Hence, improving disease management through the development of efficient treatments will prove most beneficial. Undoubtedly, these developments will require in-depth descriptions of YFV biology at molecular, physiological and ecological levels. This second section of a two-part review describes the current state of knowledge and gaps regarding the molecular biology of YFV, along with an overview of the tools that can be used to manage the disease at the individual, local and global levels.
- Subjects :
- 0301 basic medicine
Economic growth
lcsh:QH426-470
[SDV]Life Sciences [q-bio]
030231 tropical medicine
Review
Disease
Virus
World health
03 medical and health sciences
0302 clinical medicine
flavivirus
Genetics
medicine
emergence
Disease management (health)
Genetics (clinical)
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
yellow fever virus
0303 health sciences
biology
Yellow fever
Outbreak
medicine.disease
biology.organism_classification
3. Good health
virology
Vaccination
Flavivirus
lcsh:Genetics
030104 developmental biology
vector-borne transmission
Subjects
Details
- Language :
- English
- ISSN :
- 20734425
- Database :
- OpenAIRE
- Journal :
- Genes, Genes, 2018, 9 (6), pp.291. ⟨10.3390/genes9060291⟩, Genes, MDPI, 2018, 9 (6), pp.291. ⟨10.3390/genes9060291⟩, Genes, Vol 9, Iss 6, p 291 (2018)
- Accession number :
- edsair.doi.dedup.....62ac603f36dee22ca4f4834a1fd8a92d