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Forskolin modulates acetylcholine release in the hippocampus independently of adenylate cyclase activation

Forskolin modulates acetylcholine release in the hippocampus independently of adenylate cyclase activation

Authors :
Georg Hertting
Clemens Allgaier
Bong Kyo Choi
Source :
European journal of pharmacology. 181(3)
Publication Year :
1990

Abstract

[3H]Acetylcholine release from slices of rabbit hippocampus was elicited by electrical field stimulation (360 pulses/3 Hz). Both forskolin, commonly used as a specific activator of adenylate cyclase, as well as 1,9-dideoxy-for-skolin, which fails to activate adenylate cyclase, increased the evoked transmitter release in an almost identical manner. In addition, the phosphodiesterase inhibitor, rolipram, and the membrane-permeable analogue of cAMP, 8-Br-cAMP, did not influence acetylcholine release. These data show that forskolin is not specific to adenylate cyclase and that the increase in acetylcholine release in the rabbit hippocampus occurs through a mechanism other than activation of adenylate cyclase.

Details

ISSN :
00142999
Volume :
181
Issue :
3
Database :
OpenAIRE
Journal :
European journal of pharmacology
Accession number :
edsair.doi.dedup.....62effd3d25f4705606a0bd117d9f26ed