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Forskolin modulates acetylcholine release in the hippocampus independently of adenylate cyclase activation
Forskolin modulates acetylcholine release in the hippocampus independently of adenylate cyclase activation
- Source :
- European journal of pharmacology. 181(3)
- Publication Year :
- 1990
-
Abstract
- [3H]Acetylcholine release from slices of rabbit hippocampus was elicited by electrical field stimulation (360 pulses/3 Hz). Both forskolin, commonly used as a specific activator of adenylate cyclase, as well as 1,9-dideoxy-for-skolin, which fails to activate adenylate cyclase, increased the evoked transmitter release in an almost identical manner. In addition, the phosphodiesterase inhibitor, rolipram, and the membrane-permeable analogue of cAMP, 8-Br-cAMP, did not influence acetylcholine release. These data show that forskolin is not specific to adenylate cyclase and that the increase in acetylcholine release in the rabbit hippocampus occurs through a mechanism other than activation of adenylate cyclase.
- Subjects :
- medicine.medical_specialty
Adenylate kinase
8-Bromo Cyclic Adenosine Monophosphate
Biology
In Vitro Techniques
Cyclase
Hippocampus
chemistry.chemical_compound
Internal medicine
Muscarinic acetylcholine receptor M5
medicine
Animals
heterocyclic compounds
Phosphodiesterase inhibitor
Rolipram
Pharmacology
Forskolin
Colforsin
Acetylcholine
Electric Stimulation
Pyrrolidinones
Enzyme Activation
Endocrinology
chemistry
Mechanism of action
Rabbits
medicine.symptom
medicine.drug
Adenylyl Cyclases
Subjects
Details
- ISSN :
- 00142999
- Volume :
- 181
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- European journal of pharmacology
- Accession number :
- edsair.doi.dedup.....62effd3d25f4705606a0bd117d9f26ed