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Serum Reactivity against Borrelia burgdorferi OspA in Patients with Rheumatoid Arthritis
- Source :
- Clinical and Vaccine Immunology. 14:1437-1441
- Publication Year :
- 2007
- Publisher :
- American Society for Microbiology, 2007.
-
Abstract
- Lyme arthritis and rheumatoid arthritis share common clinical features and synovial histology. It is unclear whether they also share similar pathogenesis. Previous studies have shown that the severity and duration of Lyme arthritis correlate directly with serum concentrations of antibody against outer surface protein A (OspA) of the causative pathogen Borrelia burgdorferi . We tested the sera of 68 subjects with rheumatoid arthritis, 147 subjects with other autoimmune diseases, and 44 healthy subjects who had never had Lyme disease, as well as sera of 16 patients who had Lyme disease, for reactivity against the B. burgdorferi OspA protein. The sera of about a quarter of the rheumatoid arthritis patients and a 10th of the autoimmune disease and Lyme disease patients reacted against OspA antigen. Of 50 rheumatoid arthritis patients who could be evaluated for disease severity, a 28-joint count disease activity score of >2.6 was noted for 11 of 15 (73%) patients whose sera reacted against OspA antigen and 13 of 35 (37%; P < 0.05) whose sera were nonreactive. Serum reactivity against OspA antigen is associated with the pathogenesis of rheumatoid arthritis.
- Subjects :
- Adult
Male
Microbiology (medical)
Lipoproteins
Recombinant Fusion Proteins
Blotting, Western
Clinical Biochemistry
Immunology
Arthritis
Enzyme-Linked Immunosorbent Assay
Lyme Arthritis
Autoimmune Diseases
Arthritis, Rheumatoid
Lyme disease
medicine
Humans
Immunology and Allergy
Borrelia burgdorferi
Aged
Aged, 80 and over
Autoimmune disease
Antigens, Bacterial
Lyme Disease
biology
business.industry
Middle Aged
bacterial infections and mycoses
medicine.disease
biology.organism_classification
Antibodies, Bacterial
Bacterial vaccine
Rheumatoid arthritis
Antigens, Surface
Bacterial Vaccines
biology.protein
Female
Microbial Immunology
Antibody
business
Bacterial Outer Membrane Proteins
Subjects
Details
- ISSN :
- 1556679X and 15566811
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Clinical and Vaccine Immunology
- Accession number :
- edsair.doi.dedup.....630a9235929db36aa28530b316d7cc0d