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Sleep as a Therapeutic Target in the Aging Brain

Authors :
James R. Goodman
Thierno Madjou Bah
Jeffrey J. Iliff
Source :
Neurotherapeutics
Publication Year :
2019
Publisher :
Springer Science and Business Media LLC, 2019.

Abstract

Sleep is a behavioral phenomenon conserved among mammals and some invertebrates, yet the biological functions of sleep are still being elucidated. In humans, sleep time becomes shorter, more fragmented, and of poorer quality with advancing age. Epidemiologically, the development of age-related neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease is associated with pronounced sleep disruption, whereas emerging mechanistic studies suggest that sleep disruption may be causally linked to neurodegenerative pathology, suggesting that sleep may represent a key therapeutic target in the prevention of these conditions. In this review, we discuss the physiology of sleep, the pathophysiology of neurodegenerative disease, and the current literature supporting the relationship between sleep, aging, and neurodegenerative disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13311-019-00769-6) contains supplementary material, which is available to authorized users.

Details

ISSN :
18787479 and 19337213
Volume :
16
Database :
OpenAIRE
Journal :
Neurotherapeutics
Accession number :
edsair.doi.dedup.....630b04677486686ba7d12222d47b123d
Full Text :
https://doi.org/10.1007/s13311-019-00769-6