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Exploration of PDCoV-induced apoptosis through mitochondrial dynamics imbalance and the antagonistic effect of SeNPs

Authors :
Ren, Zhihua
Yu, Yueru
Zhang, Xiaojie
Wang, Qiuxiang
Deng, Junliang
Chen, Chaoxi
Shi, Riyi
Wei, Zhanyong
Hu, Hui
Source :
Frontiers in immunology. 13
Publication Year :
2022

Abstract

Porcine Deltacoronavirus (PDCoV), an enveloped positive-strand RNA virus that causes respiratory and gastrointestinal diseases, is widely spread worldwide, but there is no effective drug or vaccine against it. This study investigated the optimal Selenium Nano-Particles (SeNPs) addition concentration (2 - 10 μg/mL) and the mechanism of PDCoV effect on ST (Swine Testis) cell apoptosis, the antagonistic effect of SeNPs on PDCoV. The results indicated that 4 μg/mL SeNPs significantly decreased PDCoV replication on ST cells. SeNPs relieved PDCoV-induced mitochondrial division and antagonized PDCoV-induced apoptosis via decreasing Cyt C release and Caspase 9 and Caspase 3 activation. The above results provided an idea and experimental basis associated with anti-PDCoV drug development and clinical use.

Details

ISSN :
16643224
Volume :
13
Database :
OpenAIRE
Journal :
Frontiers in immunology
Accession number :
edsair.doi.dedup.....630ca48a03dc3b22ca405fa2110e88c8