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Anthraquinone analogues with inhibitory activities against influenza a virus from Polygonatum odoratum
- Publication Year :
- 2020
- Publisher :
- Taylor & Francis, 2020.
-
Abstract
- Three anthraquinone analogues (1–3) were isolated by phytochemical work on EtOAc-soluble ingredients extracted from the roots of Polygonatum odoratum. The structures of all isolates were elucidated by NMR, MS and CD experiments, of which 1 (polygodoquinone A) was identified as a new anthraquinone derivative. Specifically, 1 represents an unusual structure composed of a naphthoquinone derivative linked to an anthraquinone via a C-C bond. 1–3 exhibited remarkable influenza A virus inhibitory activity with IC50 values of 11.4, 11.0, and 2.3 μM, respectively, which were better than ribavirin as the positive control.
- Subjects :
- Pharmacology
Anthraquinone Analogue
Traditional medicine
biology
010405 organic chemistry
Liliaceae
Organic Chemistry
Pharmaceutical Science
General Medicine
medicine.disease_cause
biology.organism_classification
01 natural sciences
Anthraquinone
0104 chemical sciences
Analytical Chemistry
Polygonatum odoratum
010404 medicinal & biomolecular chemistry
chemistry.chemical_compound
Complementary and alternative medicine
chemistry
Phytochemical
Drug Discovery
Influenza A virus
medicine
Molecular Medicine
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....6311732bbf0bcfa82dbcbe93b6c9d7e7
- Full Text :
- https://doi.org/10.6084/m9.figshare.12841238