Back to Search
Start Over
Brain organoids as models to study human neocortex development and evolution
- Source :
- Current opinion in cell biology. 55
- Publication Year :
- 2018
-
Abstract
- Since their recent development, organoids that emulate human brain tissue have allowed in vitro neural development studies to go beyond the limits of monolayer culture systems, such as neural rosettes. We present here a review of organoid studies that focuses on cortical wall development, starting with a technical comparison between pre-patterning and self-patterning brain organoid protocols. We then follow neocortex development in space and time and list those aspects where organoids have succeeded in emulating in vivo development, as well as those aspects that continue to be pending tasks. Finally, we present a summary of medical and evolutionary insight made possible by organoid technology.
- Subjects :
- 0301 basic medicine
Neocortex
Organogenesis
Monolayer culture
Cell Culture Techniques
Cell Biology
Human brain
Biological evolution
Biology
Biological Evolution
Models, Biological
Organoids
03 medical and health sciences
030104 developmental biology
medicine.anatomical_structure
medicine
Organoid
Humans
Neuroscience
Neural development
Subjects
Details
- ISSN :
- 18790410
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Current opinion in cell biology
- Accession number :
- edsair.doi.dedup.....631dd241cc631cef4a78339882170687