Construction of Enantioenriched 4,5,6,7‐Tetrahydrofuro[2,3‐ b ]pyridines through a Multicatalytic Sequence Merging Gold and Amine Catalysis

International audience; A series of enantioenriched 4,5,6,7-tetrahydrofuro[2,3-b]pyridines were accessed by a cycloisomerization/cycloaddition strategy. Starting from ynamide derivatives and aldehydes, yields ranging from 27 to 90% and high levels of stereoselectivity (de>95%, 93–99% ee) were obtained through sequential relay catalysis. The concurrent use of a gold complex with a diphenylprolinol silyl ether was applied to a combination of diversely functionalized substrates.