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Ago-allosteric modulators of human glucagon-like peptide 2 receptor
- Source :
- Bioorganicmedicinal chemistry letters. 22(19)
- Publication Year :
- 2012
-
Abstract
- Glucagon-like peptide 2 (GLP-2) is an intestinotropic peptide that binds to GLP-2 receptor (GLP-2R), a class-B G protein-coupled receptor (GPCR). Few synthetic agonists have been reported so far for class-B GPCRs. Here, we report the first scaffold compounds of ago-allosteric modulators for human GLP-2R, derived from methyl 2-{[(2Z)-2-(2,5-dichlorothiophen-3-yl)-2-(hydroxyimino)ethyl]sulfanyl}benzoate (compound 1).
- Subjects :
- Agonist
endocrine system
medicine.drug_class
Clinical Biochemistry
Allosteric regulation
Pharmaceutical Science
Peptide
Thiophenes
Biochemistry
Benzoates
Structure-Activity Relationship
Drug Discovery
medicine
Receptors, Glucagon
Structure–activity relationship
Humans
Receptor
Molecular Biology
Glucagon-like peptide 1 receptor
G protein-coupled receptor
chemistry.chemical_classification
Dose-Response Relationship, Drug
Molecular Structure
digestive, oral, and skin physiology
Organic Chemistry
chemistry
Glucagon-Like Peptide-2 Receptor
Molecular Medicine
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 22
- Issue :
- 19
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....633a4500ac37ce8e6b7aa2e11c3b7bf9