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A new approach in organ preservation: potential role of new polymers
- Source :
- Kidney International, Kidney International, Nature Publishing Group, 2008, 74 (8), pp.998-1003. ⟨10.1038/ki.2008.336⟩
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- International audience; The storage conditions of the donor kidney may influence the deleterious consequences of ischemia/reperfusion (IR), which remains a major source of complications in clinical practice. Delayed graft function (DGF), seen in 20% to 50% of transplanted cadaver kidneys, is a major risk factor affecting early and long-term graft survival, patient management, and costs of transplantation. Cold preservation plays a key role in this process and is based on hypothermia and high potassium solutions. In this review, the authors focused on the major molecular mechanisms of cold storage (CS) injury at the cellular level, which have been recently evidenced with modern biochemical and cell biologic methods. These newly uncovered aspects of cold preservation injury are often not fully addressed by preservation solutions in current clinical practice. The role of new molecules such as polyethylene glycol (PEG) is presented and their properties are analyzed in the organ preservation context. PEG improves organ function recovery and reduces inflammation and fibrosis development in several models. Because organs shortage is also a real public health problem, organs from non-heart beating donors or marginal donors are now used to expand pool of organs. As a consequence, the development of better organ preservation methods remains a major target and deserves scientific consideration.
- Subjects :
- [SDV.SA]Life Sciences [q-bio]/Agricultural sciences
Nephrology
medicine.medical_specialty
Polymers
Organ Preservation Solutions
030232 urology & nephrology
Ischemia
Delayed Graft Function
Cold storage
polyethylene glycols
Context (language use)
[SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery
030230 surgery
Bioinformatics
Organ transplantation
03 medical and health sciences
0302 clinical medicine
Fibrosis
Internal medicine
ischemia reperfusion
Humans
Medicine
immunocamouflage
Cryopreservation
business.industry
organ transplantation
Organ Preservation
Hypothermia
medicine.disease
Kidney Transplantation
3. Good health
Surgery
Transplantation
medicine.symptom
business
Subjects
Details
- ISSN :
- 00852538 and 15231755
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- Kidney International
- Accession number :
- edsair.doi.dedup.....6348745695f2d9add1e19c1da6b2b19e