Back to Search
Start Over
The effect of repetitive exposure to intravenous anesthetic agents on the immunity in mice
- Source :
- International Journal of Medical Sciences
- Publication Year :
- 2020
- Publisher :
- Ivyspring International Publisher, 2020.
-
Abstract
- Introduction: This study was designed to assess the effect of repetitive exposure to intravenous anesthetic agents on the immunity in mice. Materials and Methods: The mice were divided into six groups: three intravenous anesthetic agents groups (dexmedetomidine, midazolam and propofol groups), and three corresponding control groups (CD, CM, and CP groups). The intravenous injections were administered once per day for 5 days. The immunity of mice was checked after the last intravenous injection. Histopathology and immunochemistry of liver and kidneys were evaluated. Cytokine levels in the blood was also checked. vs. evaluated with cytokine levels in the blood. Results: Cluster of differentiation (CD)4+ T cells were significantly less expressed in dexmedetomidine and propofol groups, compared with the corresponding control groups [34.08 ± 5.63% in the dexmedetomidine group vs. 59.74 ± 8.64% in the CD group, p < 0.05; 25.28 ± 7.28% in the propofol group vs. 61.12 ± 2.70% in the Cp group, p < 0.05]. Apoptosis of CD4+ T cells was increased significantly in dexmedetomidine and propofol groups, compared with the corresponding control groups. Histopathological findings of liver and kidneys did not show any specific differences of any of three intravenous anesthetic agents groups with their corresponding control groups, although immunohistochemical examination indicated significantly lower expression of Toll-like receptor-4 from liver and kidneys in dexmedetomidine and propofol groups. The cytokine levels were not different between the groups. Conclusion: Repetitive exposure to dexmedetomidine and propofol reduced the expression of CD4+ T cells but did not induce any significant liver or kidney injuries.
- Subjects :
- CD4-Positive T-Lymphocytes
Male
medicine.medical_specialty
Midazolam
medicine.medical_treatment
Enzyme-Linked Immunosorbent Assay
Adaptive Immunity
Pharmacology
Kidney
Mice
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Dexmedetomidine
Mice, Inbred BALB C
propofol
Cluster of differentiation
business.industry
dexmedetomidine
General Medicine
Immunohistochemistry
immunity
Cytokine
medicine.anatomical_structure
Liver
Anesthetic
intravenous anesthetic agent
030211 gastroenterology & hepatology
Histopathology
Propofol
business
Anesthetics, Intravenous
Research Paper
medicine.drug
Subjects
Details
- ISSN :
- 14491907
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- International Journal of Medical Sciences
- Accession number :
- edsair.doi.dedup.....635070f70e2f38d6703cc5bdd77c4651