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Prevention of Alzheimer's disease in high risk groups: statin therapy in subjects with PSEN1 mutations or heterozygosity for apolipoprotein E epsilon 4
- Source :
- Alzheimer's Research & Therapy
- Publication Year :
- 2010
-
Abstract
- Because cerebrospinal fl(CSF) abnormalities in presymptomatic subjects with PSEN1 (presenilin 1) mutations may be observed 4 to 12 years prior to the estimated age at onset, it is possible to test putative therapies on the CSF analytes that correlate with neurodegeneration during this presymptomatic window of clinical opportunity. It is also possible to test the same therapy on a comparison group with increased risk status conferred by both hyperlipidemia and heterozygosity for apolipoprotein Ee4. To our knowledge, the only putative therapy thus far tested in such a common design has been statin therapy. The results of these tests show increases in soluble amyloid precursor protein (sAPP)α correlating with statininduced decreases in serum cholesterol levels in the non-PSEN1 subjects. This result could be one functional correlate for part of the substantial risk reduction for late onset Alzheimer’s disease recently reported in the Rotterdam study, a large, long-term prospective statin trial. Statin therapy signifi cantly decreased both sAPPα and sAPPβ in presymptomatic PSEN1 subjects. Initially, elevated phospho-tau levels in PSEN1 subjects did not further increase during the 2 to 3 years of statin therapy, possibly indicative of a prophylactic eff ect. These results suggest that large and longer term trials of statin therapy correlating changes in CSF biomarker levels with clinical course may be warranted in both presymptomatic PSEN1 and non-PSEN1 subjects.
- Subjects :
- Oncology
Apolipoprotein E
medicine.medical_specialty
Pathology
Statin
Apolipoprotein B
medicine.drug_class
Cognitive Neuroscience
Disease
Review
Presenilin
03 medical and health sciences
Rotterdam Study
0302 clinical medicine
Internal medicine
Hyperlipidemia
medicine
PSEN1
030304 developmental biology
0303 health sciences
biology
business.industry
medicine.disease
3. Good health
Neurology
biology.protein
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 17589193
- Volume :
- 2
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Alzheimer's researchtherapy
- Accession number :
- edsair.doi.dedup.....63517b8f455b096230c20e216c627815