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Effect of arsenic trioxide on the Tregs ratio and the levels of IFN-γ, IL-4, IL-17 and TGF-β1 in the peripheral blood of severe aplastic anemia patients
- Source :
- Medicine
- Publication Year :
- 2020
- Publisher :
- Wolters Kluwer Health, 2020.
-
Abstract
- Previous studies have suggested that the anticancer agent, arsenic trioxide (ATO), could attenuate T cell mediated immunity by not only inhibiting the proliferative response of T cells but by also increasing the frequency of regulatory T cells (Tregs). Furthermore, ATO represents a reasonable salvage treatment in some patients with refractory severe aplastic anemia (SAA). The current study aimed to evaluate the function of ATO on the Tregs percentage and cytokines changes in the peripheral blood mononuclear cells (PBMCs) of SAA patients. PBMCs were collected from 20 newly diagnosed SAA patients in Henan Cancer Hospital and treated with different concentrations of ATO (0, 1, 2.5, and 5 μmol/L). Then we investigated the efficacy of ATO on Tregs ratio and the levels of interferon (IFN)-γ, interleukin (IL)-4, IL-17 and transforming growth factor (TGF)-β1 in the peripheral blood of SAA patients in vitro. The results showed that ATO significantly increased the proportion of Tregs (P .05). ATO could mediate the immune regulation, which might contribute to improve hematopoietic recovery in SAA patients.
- Subjects :
- aplastic anemia
Anemia
Tregs
Antineoplastic Agents
Apoptosis
Peripheral blood mononuclear cell
T-Lymphocytes, Regulatory
Transforming Growth Factor beta1
03 medical and health sciences
chemistry.chemical_compound
Interferon-gamma
0302 clinical medicine
Interferon
Quality Improvement Study
Medicine
Humans
030212 general & internal medicine
RNA, Messenger
Arsenic trioxide
Interleukin 4
Cells, Cultured
Dose-Response Relationship, Drug
business.industry
Macrophages
immune regulation
Interleukin-17
Interleukin
Anemia, Aplastic
Forkhead Transcription Factors
General Medicine
medicine.disease
Up-Regulation
arsenic trioxide
Haematopoiesis
chemistry
030220 oncology & carcinogenesis
Immunology
Leukocytes, Mononuclear
Interleukin 17
Interleukin-4
business
medicine.drug
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 15365964 and 00257974
- Volume :
- 99
- Issue :
- 26
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....6363d4e70990b8cfc6d0dac393aa8a2e