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Development and Characterization of a Biomimetic Totally Implantable Artificial Basilar Membrane System
- Source :
- Frontiers in Bioengineering and Biotechnology, Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
- Publication Year :
- 2021
-
Abstract
- Cochlear implants (CIs) have become the standard treatment for severe-to-profound sensorineural hearing loss. Conventional CIs have some challenges, such as the use of extracorporeal devices, and high power consumption for frequency analysis. To overcome these, artificial basilar membranes (ABMs) made of piezoelectric materials have been studied. This study aimed to verify the conceptual idea of a totally implantable ABM system. A prototype of the totally implantable system composed of the ABM developed in previous research, an electronic module (EM) for the amplification of electrical output from the ABM, and electrode was developed. We investigated the feasibility of the ABM system and obtained meaningful auditory brainstem responses of deafened guinea pigs by implanting the electrode of the ABM system. Also, an optimal method of coupling the ABM system to the human ossicle for transducing sound waves into electrical signals using the middle ear vibration was studied and the electrical signal output according to the sound stimuli was measured successfully. Although the overall power output from the ABM system is still less than the conventional CIs and further improvements to the ABM system are needed, we found a possibility of the developed ABM system as a totally implantable CIs in the future.
- Subjects :
- Histology
Computer science
medicine.medical_treatment
Biomedical Engineering
Bioengineering
02 engineering and technology
sensorineural
01 natural sciences
basilar membrane
Cochlear implant
0103 physical sciences
medicine
otorhinolaryngologic diseases
Power output
biomimetics
010301 acoustics
Sound wave
Original Research
hearing loss
cochlear implant
Bioengineering and Biotechnology
021001 nanoscience & nanotechnology
Basilar membrane
Power consumption
Biomimetics
0210 nano-technology
TP248.13-248.65
Biotechnology
Biomedical engineering
Subjects
Details
- ISSN :
- 22964185
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Frontiers in bioengineering and biotechnology
- Accession number :
- edsair.doi.dedup.....637459c7553b1136ea5619328064726e