Back to Search
Start Over
Preserved Dendritic Cell HLA-DR Expression and Reduced Regulatory T Cell Activation in Asymptomatic Plasmodium falciparum and P. vivax Infection
- Source :
- Infection and Immunity. 83:3224-3232
- Publication Year :
- 2015
- Publisher :
- American Society for Microbiology, 2015.
-
Abstract
- Clinical illness with Plasmodium falciparum or Plasmodium vivax compromises the function of dendritic cells (DC) and expands regulatory T (Treg) cells. Individuals with asymptomatic parasitemia have clinical immunity, restricting parasite expansion and preventing clinical disease. The role of DC and Treg cells during asymptomatic Plasmodium infection is unclear. During a cross-sectional household survey in Papua, Indonesia, we examined the number and activation of blood plasmacytoid DC (pDC), CD141 + , and CD1c + myeloid DC (mDC) subsets and Treg cells using flow cytometry in 168 afebrile children (of whom 15 had P. falciparum and 36 had P. vivax infections) and 162 afebrile adults (of whom 20 had P. falciparum and 20 had P. vivax infections), alongside samples from 16 patients hospitalized with uncomplicated malaria. Unlike DC from malaria patients, DC from children and adults with asymptomatic, microscopy-positive P. vivax or P. falciparum infection increased or retained HLA-DR expression. Treg cells in asymptomatic adults and children exhibited reduced activation, suggesting increased immune responsiveness. The pDC and mDC subsets varied according to clinical immunity (asymptomatic or symptomatic Plasmodium infection) and, in asymptomatic infection, according to host age and parasite species. In conclusion, active control of asymptomatic infection was associated with and likely contingent upon functional DC and reduced Treg cell activation.
- Subjects :
- Adult
Male
Adolescent
Regulatory T cell
Plasmodium falciparum
Immunology
Plasmodium vivax
Down-Regulation
Parasitemia
Lymphocyte Activation
T-Lymphocytes, Regulatory
Microbiology
Asymptomatic
Young Adult
Immune system
parasitic diseases
Malaria, Vivax
medicine
Humans
Malaria, Falciparum
Child
Asymptomatic Diseases
Host Response and Inflammation
biology
Dendritic Cells
HLA-DR Antigens
Dendritic cell
Flow Cytometry
biology.organism_classification
medicine.disease
Virology
Cross-Sectional Studies
Infectious Diseases
medicine.anatomical_structure
Indonesia
Child, Preschool
Female
Parasitology
medicine.symptom
Subjects
Details
- ISSN :
- 10985522 and 00199567
- Volume :
- 83
- Database :
- OpenAIRE
- Journal :
- Infection and Immunity
- Accession number :
- edsair.doi.dedup.....637ae7a8afef7a4bd3f2175bcd74fb10