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Quercetin and Ferulic Acid Aggravate Renal Carcinoma in Long-Term Diabetic Victims
- Source :
- Journal of Agricultural and Food Chemistry. 58:9273-9280
- Publication Year :
- 2010
- Publisher :
- American Chemical Society (ACS), 2010.
-
Abstract
- Many phytoantioxidants have therapeutic drawbacks due to their potent prooxidant bioactivity. It is hypothesized that phytoantioxidants (PAO) are beneficial only to the early-stage diabetes mellitus (DM) and will become ineffective once renopathy occurs. Gallic acid, rutin, EGCG, ferulic acid (FA), and quercetin were tried on the streptozotocin (STZ)-induced DM rat model for a 28 week experimental period. All of these PAO were shown to be ineffective for hypoglycemic action. The incidence of cataract (50%), injured glomerules, and renal cell carcinoma (RCC) was very common, among which the most severely affected involved the quercetin- and the FA-treated groups. The tumorigenicity of ferulic acid is still unclear. However, for quercetin, this can be attributted to (i) the prooxidant effect, (ii) the insulin-secretagogue bioactivity, and (iii) the competitive and noncompetitive inhibition on the O-methyltransferase to enhance the estradiol-induced tumorigenesis. Conclusively, quercetin and FA are able to aggravate, if not induce, nephrocarcinoma. It is time to reevaluate the tumorigenic detrimental effect of PAO, especially those exhibiting prooxidant bioactivity.
- Subjects :
- Male
medicine.medical_specialty
Coumaric Acids
Flavonoid
Streptozocin
Diabetes Mellitus, Experimental
Rats, Sprague-Dawley
Ferulic acid
chemistry.chemical_compound
Rutin
Internal medicine
Diabetes mellitus
medicine
Animals
heterocyclic compounds
Gallic acid
Carcinoma, Renal Cell
chemistry.chemical_classification
General Chemistry
Streptozotocin
medicine.disease
Kidney Neoplasms
Rats
Endocrinology
chemistry
Polyphenol
Quercetin
General Agricultural and Biological Sciences
medicine.drug
Subjects
Details
- ISSN :
- 15205118 and 00218561
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Journal of Agricultural and Food Chemistry
- Accession number :
- edsair.doi.dedup.....638ae37f1ec0156925894b755cc234ef