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Retinal Vessel Density in Exudative and Nonexudative Age-Related Macular Degeneration on Optical Coherence Tomography Angiography
- Source :
- Am J Ophthalmol
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- PurposeAlthough the choroid contributes to the pathogenesis of age-related macular degeneration (AMD), the role of retinal perfusion is unclear. We sought to compare retinal vascular measurements between eyes with nonexudative and exudative AMD using optical coherence tomography angiography (OCT-A).DesignRetrospective, cross-sectional study.MethodsOCT-A images were analyzed from 310 eyes of 182 patients (mean age ± standard deviation [SD], 78.8 ± 8.8 years) with nonexudative (54.2%) and exudative (45.8%) AMD to measure retinal vessel density (VD) from the superficial capillary plexus in the foveal, parafoveal, and full macular regions and foveal avascular zone (FAZ) area, perimeter, and circularity. Multivariate regressions were used to compare nonexudative and exudative AMD eyes and the impact of anti-vascular endothelial growth factor (anti-VEGF) treatments or geographic atrophy (GA).ResultsIn eyes with AMD, VD decreases with age in the foveal (β=-0.211, P < .001), parafoveal (β=-0.305, P < .001), and full macular regions (β=-0.295, P < .001). Eyes with exudative AMD demonstrated lower VD, especially in the parafoveal (29.8% ± 6.3% vs 33.0% ± 5.7%, P < .001) and full regions (27.9% ± 6.2% vs 31.2% ± 5.5%, P < .001) compared with nonexudative AMD. There were no differences in FAZ area, perimeter, or circularity between the 2 groups (P= .503-.907). In eyes with exudative AMD, previous anti-VEGF treatments did not impact retinal vascular measurements (P= .324-.986). Nonexudative AMD severity and presence of central GA also impacted retinal VD and FAZ morphology.ConclusionsRetinal VD is decreased in eyes with exudative AMD compared with nonexudative AMD but is unaffected by anti-VEGF treatments, suggesting a retinal vascular contribution to the pathogenesis of AMD.
- Subjects :
- Male
Aging
medicine.medical_specialty
genetic structures
Clinical Sciences
Neurodegenerative
Eye
Ophthalmology & Optometry
Article
Macular Degeneration
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Clinical Research
Opthalmology and Optometry
Ophthalmology
Age related
medicine
Humans
Fluorescein Angiography
Tomography
Eye Disease and Disorders of Vision
Aged
Retrospective Studies
030304 developmental biology
0303 health sciences
business.industry
Retinal Vessels
Retinal
Optical coherence tomography angiography
Macular degeneration
medicine.disease
eye diseases
Retinal vessel
Geographic atrophy
Cross-Sectional Studies
medicine.anatomical_structure
chemistry
Optical Coherence
Public Health and Health Services
030221 ophthalmology & optometry
Female
sense organs
Choroid
business
Perfusion
Tomography, Optical Coherence
Subjects
Details
- ISSN :
- 00029394
- Volume :
- 212
- Database :
- OpenAIRE
- Journal :
- American Journal of Ophthalmology
- Accession number :
- edsair.doi.dedup.....638e69dee5eac570863a5674946bcd73