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Network pharmacology: curing causal mechanisms instead of treating symptoms
- Source :
- Trends in pharmacological sciences. 43(2)
- Publication Year :
- 2021
-
Abstract
- For complex diseases, most drugs are highly ineffective, and the success rate of drug discovery is in constant decline. While low quality, reproducibility issues, and translational irrelevance of most basic and preclinical research have contributed to this, the current organ-centricity of medicine and the ‘one disease–one target–one drug’ dogma obstruct innovation in the most profound manner. Systems and network medicine and their therapeutic arm, network pharmacology, revolutionize how we define, diagnose, treat, and, ideally, cure diseases. Descriptive disease phenotypes are replaced by endotypes defined by causal, multitarget signaling modules that also explain respective comorbidities. Precise and effective therapeutic intervention is achieved by synergistic multicompound network pharmacology and drug repurposing, obviating the need for drug discovery and speeding up clinical translation.
- Subjects :
- Pharmacology
0303 health sciences
CLINICAL-RELEVANCE
PREDICTIVE BIOMARKERS
Medizin
INHIBITION
Reproducibility of Results
ATHEROPROTECTION
Network Pharmacology
Toxicology
CANCER
3. Good health
03 medical and health sciences
0302 clinical medicine
ANIMAL-MODELS
Drug Discovery
NADPH OXIDASE
Humans
BRAIN
COMBINATION
030217 neurology & neurosurgery
030304 developmental biology
Subjects
Details
- ISSN :
- 18733735
- Volume :
- 43
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Trends in pharmacological sciences
- Accession number :
- edsair.doi.dedup.....6393813bf5bff61daa5e4002f4ec53b3