Back to Search
Start Over
Development of biodegradable scaffolds based on patient-specific arterial configuration
- Source :
- Journal of Biotechnology. 133:213-218
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Biodegradable scaffolds are of great value in tissue engineering. We have developed a method for fabricating patient-specific vascular scaffolds from a biocompatible and biodegradable polymer, poly( l -lactide-co-ɛ-caprolactone). This method's usefulness is due to flexibility in the choice of materials and vascular configurations. Here, we present a way to fabricate scaffolds of human carotid artery by combining processes of rapid prototyping, lost wax, dip coating, selective dissolution, and salt leaching. The result was the successful development of porous biodegradable scaffolds, with mechanical strength covering the range of human blood vessels (1–3 MPa). Human umbilical vein endothelial cells were also cultured on the scaffolds and their biocompatibility was confirmed by cell growth. The Young's modulus of scaffolds could be controlled by changing polymer concentration and porosity. The wall thickness of the tubular scaffold was also controllable by adjusting polymer concentration and pull-up velocity during dip coating. We believe that this fabrication technique can be applied to patient-specific regeneration of blood vessels.
- Subjects :
- Materials science
Patients
Biocompatibility
Polyesters
Biocompatible Materials
Bioengineering
Sensitivity and Specificity
Applied Microbiology and Biotechnology
Dip-coating
Tissue engineering
Humans
Porosity
Cells, Cultured
chemistry.chemical_classification
Tissue Engineering
Tissue Scaffolds
Regeneration (biology)
technology, industry, and agriculture
Endothelial Cells
General Medicine
Polymer
Biodegradation
Biodegradable polymer
Elasticity
Carotid Arteries
Microscopy, Fluorescence
chemistry
Biotechnology
Biomedical engineering
Subjects
Details
- ISSN :
- 01681656
- Volume :
- 133
- Database :
- OpenAIRE
- Journal :
- Journal of Biotechnology
- Accession number :
- edsair.doi.dedup.....6398592950137cfd6e959233f9ab1fbe