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Potential Therapeutic Role of Purinergic Receptors in Cardiovascular Disease Mediated by SARS-CoV-2
- Source :
- Journal of Immunology Research, Journal of Immunology Research, Vol 2020 (2020)
- Publication Year :
- 2020
- Publisher :
- Hindawi, 2020.
-
Abstract
- Novel coronavirus disease 2019 (COVID-19) causes pulmonary and cardiovascular disorders and has become a worldwide emergency. Myocardial injury can be caused by direct or indirect damage, particularly mediated by a cytokine storm, a disordered immune response that can cause myocarditis, abnormal coagulation, arrhythmia, acute coronary syndrome, and myocardial infarction. The present review focuses on the mechanisms of this viral infection, cardiac biomarkers, consequences, and the possible therapeutic role of purinergic and adenosinergic signalling systems. In particular, we focus on the interaction of the extracellular nucleotide adenosine triphosphate (ATP) with its receptors P2X1, P2X4, P2X7, P2Y1, and P2Y2 and of adenosine (Ado) with A2A and A3 receptors, as well as their roles in host immune responses. We suggest that receptors of purinergic signalling could be ideal candidates for pharmacological targeting to protect against myocardial injury caused by a cytokine storm in COVID-19, in order to reduce systemic inflammatory damage to cells and tissues, preventing the progression of the disease by modulating the immune response and improving patient quality of life.
- Subjects :
- 0301 basic medicine
Adenosine A2 Receptor Agonists
Purinergic Antagonists
Receptor, Adenosine A2A
Immunology
Myocardial Ischemia
Adenosinergic
Review Article
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Immune system
Adenosine Triphosphate
Immunology and Allergy
Medicine
Humans
Receptor
Pandemics
business.industry
SARS-CoV-2
Purinergic receptor
Receptor, Adenosine A3
Receptors, Purinergic
COVID-19
General Medicine
RC581-607
Purinergic signalling
medicine.disease
COVID-19 Drug Treatment
030104 developmental biology
Cardiovascular Diseases
Cytokines
Immunologic diseases. Allergy
Signal transduction
business
Cytokine storm
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 23147156 and 23148861
- Volume :
- 2020
- Database :
- OpenAIRE
- Journal :
- Journal of Immunology Research
- Accession number :
- edsair.doi.dedup.....63a7492928eac8dab2aa915a61b4061a