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First Total Synthesis of Martinellic Acid, a Naturally Occurring Bradykinin Receptor Antagonist
- Source :
- Organic Letters. 3:2189-2191
- Publication Year :
- 2001
- Publisher :
- American Chemical Society (ACS), 2001.
-
Abstract
- [reaction: see text] The first total synthesis of martinellic acid, a naturally occurring bradykinin receptor antagonist, via a CuI-catalyzed coupling reaction of beta-amino ester 6 with 1,4-diiodobenzene and a guanylation reaction of secondary amine 3 under mild conditions as key steps, is described.
- Subjects :
- Plants, Medicinal
Molecular Structure
Stereochemistry
Chemistry
Receptors, Bradykinin
Organic Chemistry
Antagonist
Total synthesis
Plant Roots
Biochemistry
Coupling reaction
Structure-Activity Relationship
Alkaloids
Quinolines
Pyrroles
Amine gas treating
Amines
Physical and Theoretical Chemistry
Bradykinin receptor
Bradykinin Receptor Antagonists
Martinellic acid
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....63c9347902b01f6c1e2d95930bceb493