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CD21low B cells are predictive markers of new digital ulcers in systemic sclerosis

CD21low B cells are predictive markers of new digital ulcers in systemic sclerosis

Authors :
Antonietta Gigante
Chiara Pellicano
Edoardo Rosato
Marcella Visentini
Stefania Colantuono
Ramona Marrapodi
Milvia Casato
Giorgia Leodori
Source :
Clinical and Experimental Immunology
Publication Year :
2021
Publisher :
Oxford University Press (OUP), 2021.

Abstract

Summary The objective of this study was to evaluate the predictive role of CD21low B cells as markers of new digital ulcers in systemic sclerosis patients. Peripheral blood B cell subpopulations and clinical assessments have been evaluated in 74 systemic sclerosis patients at baseline and after a 12‐month follow‐up. After a 12‐month follow‐up, 23 (31.1%) systemic sclerosis patients developed new digital ulcers. The median percentage of CD21low B cells was significantly higher in patients with than without new digital ulcers [10.1 (4.3–13.6) versus 4.8 (3.5–7.4); p<br />CD21low B cells are increased in SSc patients. CD21low B cells are higher in SSc patients with major vascular complications. CD21low B cells may be a possible predictive marker of new DUs.

Details

ISSN :
13652249 and 00099104
Volume :
205
Database :
OpenAIRE
Journal :
Clinical and Experimental Immunology
Accession number :
edsair.doi.dedup.....63f7d0aaff8ce25774dea2bf38b1e5d1
Full Text :
https://doi.org/10.1111/cei.13604