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CD21low B cells are predictive markers of new digital ulcers in systemic sclerosis
CD21low B cells are predictive markers of new digital ulcers in systemic sclerosis
- Source :
- Clinical and Experimental Immunology
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- Summary The objective of this study was to evaluate the predictive role of CD21low B cells as markers of new digital ulcers in systemic sclerosis patients. Peripheral blood B cell subpopulations and clinical assessments have been evaluated in 74 systemic sclerosis patients at baseline and after a 12‐month follow‐up. After a 12‐month follow‐up, 23 (31.1%) systemic sclerosis patients developed new digital ulcers. The median percentage of CD21low B cells was significantly higher in patients with than without new digital ulcers [10.1 (4.3–13.6) versus 4.8 (3.5–7.4); p<br />CD21low B cells are increased in SSc patients. CD21low B cells are higher in SSc patients with major vascular complications. CD21low B cells may be a possible predictive marker of new DUs.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Multivariate analysis
systemic sclerosis
Immunology
Pulmonary arterial pressure
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
Skin Ulcer
medicine
Humans
Immunology and Allergy
In patient
B cells
CD21low
connective tissue diseases
digital ulcers
major vascular complications
raynaud's phenomenon
B cell
B-Lymphocytes
Scleroderma, Systemic
Predictive marker
business.industry
Area under the curve
Middle Aged
Peripheral blood
Confidence interval
030104 developmental biology
medicine.anatomical_structure
Autoimmunity/Autoimmune disease
Original Article
Female
Receptors, Complement 3d
ORIGINAL ARTICLES
business
Biomarkers
030215 immunology
Subjects
Details
- ISSN :
- 13652249 and 00099104
- Volume :
- 205
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Immunology
- Accession number :
- edsair.doi.dedup.....63f7d0aaff8ce25774dea2bf38b1e5d1
- Full Text :
- https://doi.org/10.1111/cei.13604