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Sarcopenia in patients after an episode of acute decompensated heart failure: An underdiagnosed problem with serious impact

Authors :
Stefan D. Anker
Ruddy Richard
Guillaume Clerfond
Yves Boirie
Pierre-Louis Tartière
Clément Riocreux
Patrick Rossignol
Bruno Pereira
Géraud Souteyrand
Nicolas Combaret
Marie Blanquet
Marie-Claire D'Agrosa Boiteux
Pascal Motreff
Aurélien Mulliez
Pelle Stolt
Frédéric Jean
Romain Eschalier
Grégoire Massoullié
CHU Clermont-Ferrand
SIGMA Clermont (SIGMA Clermont)
Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT)
Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy]
Unité de Nutrition Humaine (UNH)
Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA)
Centre de Recherche en Nutrition Humaine Auvergne [CHU Clermont-Ferrand] (CRNH A)
Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI)
CHU Clermont-Ferrand-CHU Clermont-Ferrand
CH Mauriac
Biostatistics Unit (Department of Clinical Research and Innovation)
Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
Clinique Médicale Cardio-Pneumologie de Durtol
Maglia Rotta
Défaillance Cardiovasculaire Aiguë et Chronique (DCAC)
Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)
Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P)
Centre d'investigation clinique [Nancy] (CIC)
Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)
French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT )
ROSSI, Sabine
Université de Lorraine (UL)
Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)
Institut National de la Santé et de la Recherche Médicale (INSERM)
Source :
Clinical Nutrition, Clinical Nutrition, 2021, 40 (6), pp.4490-4499. ⟨10.1016/j.clnu.2020.12.033⟩
Publication Year :
2021
Publisher :
Elsevier BV, 2021.

Abstract

International audience; Background & aims: Sarcopenia is a multifactorial syndrome resulting in a decrease in both muscle mass and function. Little is known about the prevalence and prognostic impact of sarcopenia in patients with acutely decompensated chronic heart failure (ADHF). We aimed to evaluate the prevalence (main endpoint) and impact of sarcopenia on ADHF patients.Methods: 140 ADHF patients were enrolled between November 2014 and September 2018 in a multi-center prospective longitudinal study. A similar, independent multi-departmental cross-sectional study in 165 ADHF patients was used for external validation of prevalence data. All subjects were assessed on the European Working Group on Sarcopenia criteria.Results: Ninety-one patients (65%) had sarcopenia (vs. 53.6% in the external replication regional cohort). Patients with sarcopenia were older and more likely to have eGFR

Details

ISSN :
02615614
Volume :
40
Database :
OpenAIRE
Journal :
Clinical Nutrition
Accession number :
edsair.doi.dedup.....640d83ede277932580c3d789f5f927d2