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Tumour volume doubling time of molecular breast cancer subtypes assessed by serial breast ultrasound

Tumour volume doubling time of molecular breast cancer subtypes assessed by serial breast ultrasound

Authors :
Jung Min Chang
Eun Bi Ryu
Mirinae Seo
Woo Kyung Moon
Sun Ah Kim
Ji He Lim
Source :
European Radiology. 24:2227-2235
Publication Year :
2014
Publisher :
Springer Science and Business Media LLC, 2014.

Abstract

The aim of our study was to evaluate the tumour volume doubling time (TVDT) of molecular breast cancer subtypes by serial ultrasound (US). Sixty-six patients (mean age, 50 years; range, 29–78 years) with invasive breast cancer underwent initial and follow-up breast US examinations (at least three months apart) with no intervention. TVDT was determined using the tumours’ greatest dimensions in two orthogonal planes. The results were compared with clinical, imaging, and tumour variables and molecular subtypes (oestrogen receptor [ER]-positive, human epidermal growth factor receptor 2 [HER2]-positive, and triple negative) using a multiple linear regression analysis. TVDT exhibited a wide range (46–825 days; median, 141 days) with an overall mean of 193 ± 141 days and mean values of 241 ± 166 days for ER-positive tumours (n = 37), 162 ± 60 days for HER2-positive tumours (n = 12), and 103 ± 43 days for triple-negative tumours (n = 17) (P

Details

ISSN :
14321084 and 09387994
Volume :
24
Database :
OpenAIRE
Journal :
European Radiology
Accession number :
edsair.doi.dedup.....642080f1f80af65ffc582d6b984627af
Full Text :
https://doi.org/10.1007/s00330-014-3256-0