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Tumour volume doubling time of molecular breast cancer subtypes assessed by serial breast ultrasound
Tumour volume doubling time of molecular breast cancer subtypes assessed by serial breast ultrasound
- Source :
- European Radiology. 24:2227-2235
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- The aim of our study was to evaluate the tumour volume doubling time (TVDT) of molecular breast cancer subtypes by serial ultrasound (US). Sixty-six patients (mean age, 50 years; range, 29–78 years) with invasive breast cancer underwent initial and follow-up breast US examinations (at least three months apart) with no intervention. TVDT was determined using the tumours’ greatest dimensions in two orthogonal planes. The results were compared with clinical, imaging, and tumour variables and molecular subtypes (oestrogen receptor [ER]-positive, human epidermal growth factor receptor 2 [HER2]-positive, and triple negative) using a multiple linear regression analysis. TVDT exhibited a wide range (46–825 days; median, 141 days) with an overall mean of 193 ± 141 days and mean values of 241 ± 166 days for ER-positive tumours (n = 37), 162 ± 60 days for HER2-positive tumours (n = 12), and 103 ± 43 days for triple-negative tumours (n = 17) (P
- Subjects :
- Adult
Oncology
medicine.medical_specialty
Time Factors
Multivariate analysis
Receptor, ErbB-2
medicine.medical_treatment
Breast Neoplasms
Breast cancer
Internal medicine
Biomarkers, Tumor
medicine
Humans
Doubling time
Radiology, Nuclear Medicine and imaging
Breast ultrasound
Mastectomy
Triple-negative breast cancer
Aged
Retrospective Studies
medicine.diagnostic_test
business.industry
Retrospective cohort study
General Medicine
Middle Aged
medicine.disease
Immunohistochemistry
Tumor Burden
Receptors, Estrogen
Multivariate Analysis
Disease Progression
Female
Ultrasonography, Mammary
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 14321084 and 09387994
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- European Radiology
- Accession number :
- edsair.doi.dedup.....642080f1f80af65ffc582d6b984627af
- Full Text :
- https://doi.org/10.1007/s00330-014-3256-0