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Biologically Responsive Plasmonic Assemblies for Second Near-Infrared Window Photoacoustic Imaging-Guided Concurrent Chemo-Immunotherapy
- Source :
- ACS nano. 14(4)
- Publication Year :
- 2020
-
Abstract
- We developed dual biologically responsive nanogapped gold nanoparticle vesicles loaded with immune inhibitor and carrying an anticancer polymeric prodrug for synergistic concurrent chemo-immunotherapy against primary and metastatic tumors, along with guided cargo release by photoacoustic (PA) imaging in the second near-infrared (NIR-II) window. The responsive vesicle was prepared by self-assembly of nanogapped gold nanoparticles (AuNNPs) grafted with poly(ethylene glycol) (PEG) and dual pH/GSH-responsive polyprodug poly(SN38-co-4-vinylpyridine) (termed AuNNP@PEG/PSN38VP), showing intense PA signal in the NIR-II window. The effect of the rigidity of hydrophobic polymer PSN38VP on the assembled structures and the formation mechanism of AuNNP@SN38 Ve were elucidated by computational simulations. The immune inhibitor BLZ-945 was encapsulated into the vesicles, resulting in pH-responsive release of BLZ-945 for targeted immunotherapy, followed by the dissociation of the vesicles into single AuNNP@PEG/PSN38VP. The hydrophilic AuNNP@PEG/PSN38VP nanoparticles could penetrate deep into the tumor tissues and release the anticancer drug SN38 under the reductive environment. A PA signal in the NIR-II window in the deep tumor region was obtained. The BLZ-945-loaded vesicle enabled enhanced PA imaging-guided concurrent chemo-immunotherapy efficacy, inhibiting the growth of both primary tumors and metastatic tumors.
- Subjects :
- Polymers
General Physics and Astronomy
Photoacoustic imaging in biomedicine
Nanoparticle
Metal Nanoparticles
02 engineering and technology
010402 general chemistry
01 natural sciences
Photoacoustic Techniques
chemistry.chemical_compound
PEG ratio
General Materials Science
Plasmon
Chemo immunotherapy
Chemistry
Vesicle
technology, industry, and agriculture
General Engineering
021001 nanoscience & nanotechnology
0104 chemical sciences
Colloidal gold
Biophysics
Nanoparticles
Gold
Immunotherapy
0210 nano-technology
Ethylene glycol
Subjects
Details
- ISSN :
- 1936086X
- Volume :
- 14
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- ACS nano
- Accession number :
- edsair.doi.dedup.....64244d8ea64778b662eae3729a49f77f