Total Synthesis and Antibacterial Properties of Carbaplatensimycin

Authors :: Antonia F. Stepan
Jianhua Wang
Yefeng Tang
and Ang Li
Ana Montero
Kyriacos C. Nicolaou
Source :: Journal of the American Chemical Society. 129:14850-14851
Publication Year :: 2007
Publisher :: American Chemical Society (ACS), 2007.
Abstract: The chemical synthesis and biological evaluation of carbaplatensimycin, the carbon analogue of the recently reported antibiotic platensimycin has been accomplished. Carbaplatensimycin exhibited similar potency to the natural product as an antibacterial agent against a variety of strains, including methicilin- and vancomycin-resistant bacteria.