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Plasma folate, vitamin B12, and homocysteine and cancers of the esophagus, stomach, and liver in a Chinese population
- Source :
- Nutrition and cancer, vol 67, iss 2
- Publication Year :
- 2015
- Publisher :
- eScholarship, University of California, 2015.
-
Abstract
- Evidence is accumulating regarding a role of micronutrients in folate metabolism in cancer risk. We investigated the associations of plasma folate, vitamin B12, and homocysteine with upper gastrointestinal (GI) cancers in a population-based case-control study in Taixing City, China. With informed consent, we recruited cases with cancers of esophagus (n = 218), stomach (n = 206), and liver (n = 204), and one common healthy control group (n = 405). A standardized epidemiologic questionnaire was used in face-to-face interviews, and blood samples were collected during interviews. We observed an inverse association between plasma folate levels and liver cancer. The adjusted odds ratio (aOR) was 0.46 [95% confidence interval (CI) = 0.24–0.88] comparing individuals in the highest quartile to those in the lowest. We found a positive association between plasma vitamin B12 levels and all three cancers. The aORs for those in the highest quartile were 2.80 (95% CI = 1.51–5.18) for esophageal cancer, 2.17 (1.21–3.89) for stomach cancer, and 9.97 (4.82–20.60) for liver cancer, comparing to those in the lowest quartile. We further observed interaction between plasma folate and vitamin B12 on these cancers. Our data indicated associations between plasma folate and vitamin B12 with upper GI cancers in Chinese population. Further research is warranted considering the debate over the necessity of food fortification.
- Subjects :
- Male
Cancer Research
Pathology
Esophageal Neoplasms
Medicine (miscellaneous)
Gastroenterology
Oral and gastrointestinal
Risk Factors
Surveys and Questionnaires
Odds Ratio
Stomach cancer
Homocysteine
Cancer
education.field_of_study
Nutrition and Dietetics
Liver Neoplasms
Esophageal cancer
Middle Aged
Micronutrient
Vitamin B 12
Oncology
Quartile
Female
Liver cancer
Adult
medicine.medical_specialty
China
Population
Oncology and Carcinogenesis
Article
Folic Acid
Rare Diseases
Stomach Neoplasms
Clinical Research
Internal medicine
Complementary and Integrative Health
medicine
Humans
Vitamin B12
education
Aged
Nutrition
Nutrition & Dietetics
business.industry
Prevention
Odds ratio
medicine.disease
Case-Control Studies
business
Digestive Diseases
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Nutrition and cancer, vol 67, iss 2
- Accession number :
- edsair.doi.dedup.....64b2b39faed5459f6cba390fc0ecb945