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Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis
- Source :
- Mediators of Inflammation, Mediators of Inflammation, Vol 2020 (2020)
- Publication Year :
- 2020
- Publisher :
- Hindawi, 2020.
-
Abstract
- Given the growing evidence of a link between gut microbiota (GM) dysbiosis and multiple sclerosis (MS), fecal microbiota transplantation (FMT), aimed at rebuilding GM, has been proposed as a new therapeutic approach to MS treatment. To evaluate the viability of FMT for MS treatment and its impact on MS pathology, we tested FMT in mice with experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. We provide evidence that FMT can rectify altered GM to some extent with a therapeutic effect on EAE. We also found that FMT led to reduced activation of microglia and astrocytes and conferred protection on the blood-brain barrier (BBB), myelin, and axons in EAE. Taken together, our data suggest that FMT, as a GM-based therapy, has the potential to be an effective treatment for MS.
- Subjects :
- 0301 basic medicine
Multiple Sclerosis
Article Subject
Immunology
Blotting, Western
Fluorescent Antibody Technique
Gut flora
03 medical and health sciences
Therapeutic approach
Myelin
Feces
Mice
0302 clinical medicine
Microscopy, Electron, Transmission
RNA, Ribosomal, 16S
medicine
Pathology
RB1-214
Animals
Myelin Sheath
biology
Microglia
business.industry
Multiple sclerosis
Experimental autoimmune encephalomyelitis
Therapeutic effect
Cell Biology
Fecal Microbiota Transplantation
medicine.disease
biology.organism_classification
Axons
Gastrointestinal Microbiome
Mice, Inbred C57BL
Disease Models, Animal
030104 developmental biology
medicine.anatomical_structure
Blood-Brain Barrier
Female
business
Dysbiosis
030217 neurology & neurosurgery
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 09629351
- Database :
- OpenAIRE
- Journal :
- Mediators of Inflammation
- Accession number :
- edsair.doi.dedup.....64c35162c97b2712ed6092e134b3738c
- Full Text :
- https://doi.org/10.1155/2020/2058272