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Osteopontin concentrations are increased in cerebrospinal fluid during attacks of multiple sclerosis
- Source :
- Multiple Sclerosis Journal. 17:32-42
- Publication Year :
- 2010
- Publisher :
- SAGE Publications, 2010.
-
Abstract
- Background:The cytokine osteopontin (OPN) is a potential key player in the immunopathogenesis of multiple sclerosis (MS) and a candidate biomarker for disease activity. Objective:The objective of this study was to examine concentrations of OPN in the cerebrospinal fluid (CSF) across the clinical spectrum of MS. Methods:Our research consisted of a cross-sectional study of patients from two randomized, placebo-controlled trials. Concentrations of OPN and other blood and CSF markers were determined using an enzyme-linked immunosorbent assay (ELISA). Samples were obtained from untreated patients with exacerbation of clinically isolated syndrome (CIS) ( n = 25) and relapsing–remitting MS (RRMS) ( n = 41) of whom 48 participated in clinical trials, randomly allocated to treatment with placebo or methylprednisolone (MP) and undergoing repeated sampling after 3 weeks. Furthermore, we obtained CSF and blood samples from patients with primary progressive MS (PPMS, n = 9), secondary progressive MS (SPMS, n = 28) and other neurological disorders (OND, n = 44), and blood samples from 24 healthy subjects. Results:OPN concentrations were significantly increased in the CSF of patients with CIS ( p = 0.02) and RRMS ( p Conclusions:OPN concentration in the CSF is a dynamic indicator of disease activity in RRMS, presumably reflecting ongoing inflammation. Increased CSF OPN concentrations in PPMS may indicate ongoing inflammation even in these patients.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Time Factors
Exacerbation
Enzyme-Linked Immunosorbent Assay
Placebo
Methylprednisolone
Gastroenterology
Central nervous system disease
Disability Evaluation
Multiple Sclerosis, Relapsing-Remitting
Cerebrospinal fluid
stomatognathic system
Internal medicine
medicine
Humans
Glucocorticoids
Randomized Controlled Trials as Topic
Clinically isolated syndrome
business.industry
Multiple sclerosis
Middle Aged
Multiple Sclerosis, Chronic Progressive
medicine.disease
Up-Regulation
Cross-Sectional Studies
Diffusion Magnetic Resonance Imaging
Treatment Outcome
Neurology
Biomarker (medicine)
Female
Osteopontin
Neurology (clinical)
business
Demyelinating Diseases
medicine.drug
Subjects
Details
- ISSN :
- 14770970 and 13524585
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Multiple Sclerosis Journal
- Accession number :
- edsair.doi.dedup.....64d750869ec0b9ee292395d39831e0cd