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Influence of captopril on cis-diamminedichloroplatinum-induced renal toxicity
- Source :
- American Journal of Nephrology, 5(6), 433-436. KARGER
- Publication Year :
- 1985
-
Abstract
- Renal function studies were performed in 18 patients with nonseminomatous testicular cancer during four platinum-containing chemotherapy courses. The first 9 patients received chemotherapy alone, the second 9 also captopril, an angiotensin I converting enzyme inhibitor, in order to prevent cis-diamminedichloroplatinum-induced nephrotoxicity. In the first group a decrease in glomerular filtration rate, that was preceded by a fall in effective renal plasma flow, was observed. In the second group, captopril was able to prevent the initial decrease in effective renal plasma flow, but failed to prevent the ultimate decrease in glomerular filtration rate.
- Subjects :
- Adult
Male
medicine.medical_specialty
Captopril
medicine.medical_treatment
Urology
Renal function
urologic and male genital diseases
Kidney
Nephrotoxicity
Nephropathy
Renal Circulation
Testicular Neoplasms
Internal medicine
medicine
Humans
Testicular cancer
Chemotherapy
Clinical Trials as Topic
business.industry
Effective renal plasma flow
Middle Aged
medicine.disease
Endocrinology
Nephrology
Toxicity
Cisplatin
business
medicine.drug
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 02508095
- Volume :
- 5
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- American journal of nephrology
- Accession number :
- edsair.doi.dedup.....64df5a8755cf398b2cf55a9cbd5462ee