Back to Search Start Over

Influence of captopril on cis-diamminedichloroplatinum-induced renal toxicity

Authors :
Sytze Meijer
Nanno Mulder
Dirk Sleijfer
Gk Vanderhem
Hs Koops
Ajm Donker
Jjg Offerman
Source :
American Journal of Nephrology, 5(6), 433-436. KARGER
Publication Year :
1985

Abstract

Renal function studies were performed in 18 patients with nonseminomatous testicular cancer during four platinum-containing chemotherapy courses. The first 9 patients received chemotherapy alone, the second 9 also captopril, an angiotensin I converting enzyme inhibitor, in order to prevent cis-diamminedichloroplatinum-induced nephrotoxicity. In the first group a decrease in glomerular filtration rate, that was preceded by a fall in effective renal plasma flow, was observed. In the second group, captopril was able to prevent the initial decrease in effective renal plasma flow, but failed to prevent the ultimate decrease in glomerular filtration rate.

Details

ISSN :
02508095
Volume :
5
Issue :
6
Database :
OpenAIRE
Journal :
American journal of nephrology
Accession number :
edsair.doi.dedup.....64df5a8755cf398b2cf55a9cbd5462ee