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A Diagnostic Biomarker for Pediatric Generalized Anxiety Disorder Using the Error-Related Negativity
- Source :
- Child Psychiatry Hum Dev
- Publication Year :
- 2020
-
Abstract
- The error-related negativity (ERN) is a negative deflection in the event-related potential following a mistake that is a putative biomarker of anxiety. The study assessed the ERN as a diagnostic biomarker using receiver operating characteristic (ROC) analyses in 96 cases with anxiety disorders (AD) and 96 matched healthy controls (HC) ages 8 to 18 years. Forty-one cases had generalized anxiety disorder (GAD); 55 cases had other anxiety disorders (OAD) without GAD. ERN amplitude was significantly increased in AD cases compared to HC. The area under the curve (AUC) in the ROC analysis was 0.64, indicating the ERN is an inadequate diagnostic test for AD altogether. The ERN was significantly increased in cases with either GAD or OAD compared to HC. The AUC in ROC analyses with GAD and OAD was 0.75 and 0.56, respectively, suggesting the ERN provides an adequate diagnostic test for GAD but not for OAD.
- Subjects :
- Oncology
Male
050103 clinical psychology
medicine.medical_specialty
Generalized anxiety disorder
Adolescent
behavioral disciplines and activities
Article
Error-related negativity
Internal medicine
Developmental and Educational Psychology
medicine
Diagnostic biomarker
Humans
0501 psychology and cognitive sciences
Child
Evoked Potentials
Receiver operating characteristic
05 social sciences
Area under the curve
Diagnostic test
Negativity effect
Electroencephalography
medicine.disease
Anxiety Disorders
Psychiatry and Mental health
Pediatrics, Perinatology and Child Health
Anxiety
Female
medicine.symptom
Psychology
Biomarkers
050104 developmental & child psychology
Subjects
Details
- ISSN :
- 15733327
- Volume :
- 51
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Child psychiatry and human development
- Accession number :
- edsair.doi.dedup.....64eb975c05008b08d370c8fdd405febe