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Measurement of cerebral vascular reserves with I-123 IMP SPECT without an arterial input function using the microsphere model and radiopharmaceutical dose calibration
- Source :
- Annals of nuclear medicine. 33(6)
- Publication Year :
- 2018
-
Abstract
- Cerebral vascular reserve (CVR) is an important indicator for the management of and therapy for cerebral arterial occlusive disease (CAOD). Vasodilatory function is measured using the standard IMP-ARG method. The IMP autoradiography (IMP-ARG) method employed here uses a standardized input function, which was derived from 12 patients between 31 and 71 years of age. Because the population of elderly patients continues to increase in Japan, additional therapies are required to assess CVR in elderly patients with chronic cardiopulmonary disease or a history of smoking, in particular. Despite its popularity, alternatives to the IMP-ARG method are necessary. Here, we proposed the microsphere (MS) method without an input function. Using this method and the IMP-ARG method, we measured the CVRs of 18 CAOD patients. The CVRs derived with these two methods were significantly and linearly correlated (r = 0.89, p
- Subjects :
- Adult
Male
medicine.medical_specialty
Population
Radiation Dosage
Models, Biological
Microsphere
Internal medicine
Calibration
medicine
Humans
Radiology, Nuclear Medicine and imaging
Arterial input function
education
Chronic cardiopulmonary disease
Aged
Tomography, Emission-Computed, Single-Photon
education.field_of_study
business.industry
General Medicine
Middle Aged
Iofetamine
Microspheres
Cerebral blood flow
Cerebrovascular Circulation
Cardiology
Female
Radiopharmaceuticals
Acetazolamide
business
I 123 imp
medicine.drug
Subjects
Details
- ISSN :
- 18646433
- Volume :
- 33
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Annals of nuclear medicine
- Accession number :
- edsair.doi.dedup.....64faa8efd68dc065070e93673a23a136